The role of the interleukin-1/Toll-like receptor superfamily in inflammation and host defence
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2000-08-30Keywords
Adaptor Proteins, Signal TransducingAnimals
Antigens, Differentiation
*Drosophila Proteins
Forecasting
Gram-Negative Bacteria
Gram-Positive Bacteria
Humans
Immunity, Innate
Inflammation
Membrane Glycoproteins
Myeloid Differentiation Factor 88
Plant Diseases
Plant Proteins
Receptors, Cell Surface
*Receptors, Immunologic
Receptors, Interleukin-1
Toll-Like Receptors
Immunology and Infectious Disease
Metadata
Show full item recordAbstract
The IL-1 receptor/Toll-like receptor superfamily comprises a diverse family of cell surface receptors defined by a characteristic conserved sequence in their cytosolic regions, termed the Toll/IL-1 receptor domain, which function in inflammation and host defence against microbial pathogens. Members include receptors for the proinflammatory cytokines IL-1 and IL-18 and Toll-like receptors 2 and 4, which are involved in host responses to Gram-positive and Gram-negative bacteria, respectively. Signalling pathways activated by these receptors are conserved and the superfamily represents a pan-genomic system involved in the host response to infection and injury.Source
Microbes Infect. 2000 Jul;2(8):933-43.Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34872PubMed ID
10962277Related Resources
Link to Article in PubMedCollections
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