Show simple item record

dc.contributor.authorUnterholzner, Leonie
dc.contributor.authorKeating, Sinead E.
dc.contributor.authorBaran, Marcin
dc.contributor.authorHoran, Kristy A.
dc.contributor.authorJensen, Soren B.
dc.contributor.authorSharma, Shrutie
dc.contributor.authorSirois, Cherilyn M.
dc.contributor.authorJin, Tengchuan
dc.contributor.authorLatz, Eicke
dc.contributor.authorXiao, T. Sam
dc.contributor.authorFitzgerald, Katherine A.
dc.contributor.authorPaludan, Soren R.
dc.contributor.authorBowie, Andrew G.
dc.date2022-08-11T08:09:08.000
dc.date.accessioned2022-08-23T16:18:44Z
dc.date.available2022-08-23T16:18:44Z
dc.date.issued2010-11-05
dc.date.submitted2011-04-07
dc.identifier.citationNat Immunol. 2010 Nov;11(11):997-1004. Epub 2010 Oct 3. <a href="http://dx.doi.org/10.1038/ni.1932">Link to article on publisher's site</a>
dc.identifier.issn1529-2908 (Linking)
dc.identifier.doi10.1038/ni.1932
dc.identifier.pmid20890285
dc.identifier.urihttp://hdl.handle.net/20.500.14038/34886
dc.description.abstractThe detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-beta (IFN-beta). IFI16 directly associated with IFN-beta-inducing viral DNA motifs. STING, a critical mediator of IFN-beta responses to DNA, was recruited to IFI16 after DNA stimulation. Lowering the expression of IFI16 or its mouse ortholog p204 by RNA-mediated interference inhibited gene induction and activation of the transcription factors IRF3 and NF-kappaB induced by DNA and herpes simplex virus type 1 (HSV-1). IFI16 (p204) is the first PYHIN protein to our knowledge shown to be involved in IFN-beta induction. Thus, the PYHIN proteins IFI16 and AIM2 form a new family of innate DNA sensors we call 'AIM2-like receptors' (ALRs).
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=20890285&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/ni.1932
dc.subjectAnimals
dc.subjectCell Line
dc.subjectDNA, Viral
dc.subjectHerpesvirus 1, Human
dc.subjectHumans
dc.subject*Immunity, Innate
dc.subjectInterferon-beta
dc.subjectIntracellular Space
dc.subjectMembrane Proteins
dc.subjectMice
dc.subjectMonocytes
dc.subjectNuclear Proteins
dc.subjectPhosphoproteins
dc.subjectSignal Transduction
dc.subjectImmunology and Infectious Disease
dc.titleIFI16 is an innate immune sensor for intracellular DNA
dc.typeJournal Article
dc.source.journaltitleNature immunology
dc.source.volume11
dc.source.issue11
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/infdis_pp/114
dc.identifier.contextkey1924819
html.description.abstract<p>The detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA sensor that mediates the induction of interferon-beta (IFN-beta). IFI16 directly associated with IFN-beta-inducing viral DNA motifs. STING, a critical mediator of IFN-beta responses to DNA, was recruited to IFI16 after DNA stimulation. Lowering the expression of IFI16 or its mouse ortholog p204 by RNA-mediated interference inhibited gene induction and activation of the transcription factors IRF3 and NF-kappaB induced by DNA and herpes simplex virus type 1 (HSV-1). IFI16 (p204) is the first PYHIN protein to our knowledge shown to be involved in IFN-beta induction. Thus, the PYHIN proteins IFI16 and AIM2 form a new family of innate DNA sensors we call 'AIM2-like receptors' (ALRs).</p>
dc.identifier.submissionpathinfdis_pp/114
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.source.pages997-1004


This item appears in the following Collection(s)

Show simple item record