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dc.contributor.authorNoppert, Susie J.
dc.contributor.authorFitzgerald, Katherine A.
dc.contributor.authorHertzog, Paul J.
dc.date2022-08-11T08:09:08.000
dc.date.accessioned2022-08-23T16:18:47Z
dc.date.available2022-08-23T16:18:47Z
dc.date.issued2007-08-02
dc.date.submitted2011-04-07
dc.identifier.citationImmunol Cell Biol. 2007 Aug-Sep;85(6):446-57. Epub 2007 Jul 31. <a href="http://dx.doi.org/10.1038/sj.icb.7100099">Link to article on publisher's site</a>
dc.identifier.issn0818-9641 (Linking)
dc.identifier.doi10.1038/sj.icb.7100099
dc.identifier.pmid17667935
dc.identifier.urihttp://hdl.handle.net/20.500.14038/34896
dc.description.abstractRecent advances in unravelling the complexities of the signalling pathways that constitute innate immunity have highlighted type I interferon as a key component in the response to infection. Here we focus on the emerging field of pattern-recognition receptor signalling, specifically Toll-like receptors and retinoic acid inducible gene-like helicases, from the perspective of this 50-year-old cytokine. The type I interferon gene family encompasses more than 20 subtypes, whose nature and properties have been extensively studied during its relatively long history. In this review we update and integrate available data on the mechanics of activation of the interferon genes and the role of this cytokine family in the innate immune response.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=17667935&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/sj.icb.7100099
dc.subjectAnimals
dc.subjectBase Sequence
dc.subjectCommunicable Diseases
dc.subjectHumans
dc.subjectInterferon Type I
dc.subjectMolecular Sequence Data
dc.subjectReceptors, Interferon
dc.subjectSignal Transduction
dc.subjectToll-Like Receptors
dc.subjectTranscription, Genetic
dc.subjectImmunology and Infectious Disease
dc.titleThe role of type I interferons in TLR responses
dc.typeJournal Article
dc.source.journaltitleImmunology and cell biology
dc.source.volume85
dc.source.issue6
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/infdis_pp/123
dc.identifier.contextkey1924828
html.description.abstract<p>Recent advances in unravelling the complexities of the signalling pathways that constitute innate immunity have highlighted type I interferon as a key component in the response to infection. Here we focus on the emerging field of pattern-recognition receptor signalling, specifically Toll-like receptors and retinoic acid inducible gene-like helicases, from the perspective of this 50-year-old cytokine. The type I interferon gene family encompasses more than 20 subtypes, whose nature and properties have been extensively studied during its relatively long history. In this review we update and integrate available data on the mechanics of activation of the interferon genes and the role of this cytokine family in the innate immune response.</p>
dc.identifier.submissionpathinfdis_pp/123
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.source.pages446-57


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