Sorting out Toll signals

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Authors
Fitzgerald, Katherine A.
Chen, Zhijian J.
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and Immunology
Document Type
Journal Article
Publication Date
2006-06-06
Keywords
Adaptor Proteins, Signal Transducing
Animals
Humans
Membrane Glycoproteins
Membrane Lipids
Myeloid Differentiation Factor 88
Phosphatidylinositol 4,5-Diphosphate
Phospholipids
Protein Transport
Receptors, Interleukin-1

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Link to Full Text
http://dx.doi.org/10.1016/j.cell.2006.05.014
Abstract
Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.
Source
Cell. 2006 Jun 2;125(5):834-6. Link to article on publisher's site
DOI
10.1016/j.cell.2006.05.014
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34898
PubMed ID
16751092
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