Sorting out Toll signals
| dc.contributor.author | Fitzgerald, Katherine A. | |
| dc.contributor.author | Chen, Zhijian J. | |
| dc.date | 2022-08-11T08:09:08.000 | |
| dc.date.accessioned | 2022-08-23T16:18:47Z | |
| dc.date.available | 2022-08-23T16:18:47Z | |
| dc.date.issued | 2006-06-06 | |
| dc.date.submitted | 2011-04-07 | |
| dc.identifier.citation | Cell. 2006 Jun 2;125(5):834-6. <a href="http://dx.doi.org/10.1016/j.cell.2006.05.014">Link to article on publisher's site</a> | |
| dc.identifier.issn | 0092-8674 (Linking) | |
| dc.identifier.doi | 10.1016/j.cell.2006.05.014 | |
| dc.identifier.pmid | 16751092 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/34898 | |
| dc.description.abstract | Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16751092&dopt=Abstract">Link to Article in PubMed</a> | |
| dc.relation.url | http://dx.doi.org/10.1016/j.cell.2006.05.014 | |
| dc.subject | Adaptor Proteins, Signal Transducing | |
| dc.subject | Animals | |
| dc.subject | Humans | |
| dc.subject | Membrane Glycoproteins | |
| dc.subject | Membrane Lipids | |
| dc.subject | Myeloid Differentiation Factor 88 | |
| dc.subject | Phosphatidylinositol 4,5-Diphosphate | |
| dc.subject | Phospholipids | |
| dc.subject | Protein Transport | |
| dc.subject | Receptors, Interleukin-1 | |
| dc.subject | Signal Transduction | |
| dc.subject | Toll-Like Receptor 4 | |
| dc.subject | Toll-Like Receptors | |
| dc.subject | Immunology and Infectious Disease | |
| dc.title | Sorting out Toll signals | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Cell | |
| dc.source.volume | 125 | |
| dc.source.issue | 5 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/infdis_pp/125 | |
| dc.identifier.contextkey | 1924830 | |
| html.description.abstract | <p>Upon recognition of microbial products, Toll-like receptors (TLRs) recruit distinct combinations of adaptors to induce TLR-specific gene expression. In this issue, Kagan and Medzhitov (2006) demonstrate that the adaptor TIRAP/Mal localizes to the plasma membrane by binding to phosphatidylinositol 4,5-bisphosphate (PIP2). This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism.</p> | |
| dc.identifier.submissionpath | infdis_pp/125 | |
| dc.contributor.department | Department of Medicine, Division of Infectious Diseases and Immunology | |
| dc.source.pages | 834-6 |
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