Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway
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Authors
Boyer, LaurentMagoc, Lorin
Dejardin, Stephanie
Cappillino, Michael
Paquette, Nicholas Paul
Hinault, Charlotte
Charriere, Guillaume M.
Ip, W. K. Eddie
Fracchia, Shannon
Hennessy, Elizabeth
Erturk Hasdemir, Deniz
Reichhart, Jean-Marc
Silverman, Neal S.
Lucy-Hulbert, Adam
Stuart, Lynda M.
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2011-10-28Keywords
Adaptor Proteins, Signal TransducingEnzyme Activation
HEK293 Cells
Humans
Receptor-Interacting Protein Serine-Threonine Kinases
*Signal Transduction
rac GTP-Binding Proteins
Immunology and Infectious Disease
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Show full item recordAbstract
Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response accordingly. Here, focusing on cytotoxic necrotizing factor 1 (CNF1), an Escherichia coli-derived effector molecule, we showed the host indirectly sensed the pathogen by monitoring for the effector that modified RhoGTPases. CNF1 modified Rac2, which then interacted with the innate immune adaptors IMD and Rip1-Rip2 in flies and mammalian cells, respectively, to drive an immune response. This response was protective and increased the ability of the host to restrict pathogen growth, thus defining a mechanism of effector-triggered immunity that contributes to how metazoans defend against microbes with pathogenic potential.Source
Immunity. 2011 Oct 28;35(4):536-49. doi: 10.1016/j.immuni.2011.08.015. Link to article on publisher's siteDOI
10.1016/j.immuni.2011.08.015Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34931PubMed ID
22018470Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.immuni.2011.08.015