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    Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway

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    Authors
    Boyer, Laurent
    Magoc, Lorin
    Dejardin, Stephanie
    Cappillino, Michael
    Paquette, Nicholas Paul
    Hinault, Charlotte
    Charriere, Guillaume M.
    Ip, W. K. Eddie
    Fracchia, Shannon
    Hennessy, Elizabeth
    Erturk Hasdemir, Deniz
    Reichhart, Jean-Marc
    Silverman, Neal S.
    Lucy-Hulbert, Adam
    Stuart, Lynda M.
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    UMass Chan Affiliations
    Department of Medicine, Division of Infectious Diseases and Immunology
    Document Type
    Journal Article
    Publication Date
    2011-10-28
    Keywords
    Adaptor Proteins, Signal Transducing
    Enzyme Activation
    HEK293 Cells
    Humans
    Receptor-Interacting Protein Serine-Threonine Kinases
    *Signal Transduction
    rac GTP-Binding Proteins
    Immunology and Infectious Disease
    
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    Link to Full Text
    http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3258503/pdf/nihms331006.pdf
    Abstract
    Although infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response accordingly. Here, focusing on cytotoxic necrotizing factor 1 (CNF1), an Escherichia coli-derived effector molecule, we showed the host indirectly sensed the pathogen by monitoring for the effector that modified RhoGTPases. CNF1 modified Rac2, which then interacted with the innate immune adaptors IMD and Rip1-Rip2 in flies and mammalian cells, respectively, to drive an immune response. This response was protective and increased the ability of the host to restrict pathogen growth, thus defining a mechanism of effector-triggered immunity that contributes to how metazoans defend against microbes with pathogenic potential.
    Source
    Immunity. 2011 Oct 28;35(4):536-49. doi: 10.1016/j.immuni.2011.08.015. Link to article on publisher's site
    DOI
    10.1016/j.immuni.2011.08.015
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34931
    PubMed ID
    22018470
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.immuni.2011.08.015
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