Pathogen-derived effectors trigger protective immunity via activation of the Rac2 enzyme and the IMD or Rip kinase signaling pathway
Paquette, Nicholas Paul
Charriere, Guillaume M.
Ip, W. K. Eddie
Erturk Hasdemir, Deniz
Silverman, Neal S.
Stuart, Lynda M.
UMass Chan AffiliationsDepartment of Medicine, Division of Infectious Diseases and Immunology
Document TypeJournal Article
KeywordsAdaptor Proteins, Signal Transducing
Receptor-Interacting Protein Serine-Threonine Kinases
rac GTP-Binding Proteins
Immunology and Infectious Disease
MetadataShow full item record
AbstractAlthough infections with virulent pathogens often induce a strong inflammatory reaction, what drives the increased immune response to pathogens compared to nonpathogenic microbes is poorly understood. One possibility is that the immune system senses the level of threat from a microorganism and augments the response accordingly. Here, focusing on cytotoxic necrotizing factor 1 (CNF1), an Escherichia coli-derived effector molecule, we showed the host indirectly sensed the pathogen by monitoring for the effector that modified RhoGTPases. CNF1 modified Rac2, which then interacted with the innate immune adaptors IMD and Rip1-Rip2 in flies and mammalian cells, respectively, to drive an immune response. This response was protective and increased the ability of the host to restrict pathogen growth, thus defining a mechanism of effector-triggered immunity that contributes to how metazoans defend against microbes with pathogenic potential.
SourceImmunity. 2011 Oct 28;35(4):536-49. doi: 10.1016/j.immuni.2011.08.015. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/34931
Related ResourcesLink to Article in PubMed