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    The Drosophila IMD pathway in the activation of the humoral immune response

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    Authors
    Kleino, Anni
    Silverman, Neal S.
    UMass Chan Affiliations
    Department of Medicine, Division of Infectious Diseases and Immunology
    Document Type
    Journal Article
    Publication Date
    2014-01-01
    Keywords
    Immune response
    NF-κB signaling
    Drosophila
    Immunity
    Immunology and Infectious Disease
    
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    Link to Full Text
    http://dx.doi.org/10.1016/j.dci.2013.05.014
    Abstract
    The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria. During the last two decades, significant progress has been made in identifying the components and deciphering the molecular mechanisms underlying this pathway, including the means of bacterial sensing and signal transduction. While these findings have contributed to the understanding of the immune signaling in insects, they have also provided new insights in studying the mammalian NF-kappaB signaling pathways. Here, we summarize the current view of the IMD pathway focusing on how it regulates the humoral immune response of Drosophila.
    Source
    Kleino A, Silverman N. The Drosophila IMD pathway in the activation of the humoral immune response. Dev Comp Immunol. 2014 Jan;42(1):25-35. doi:10.1016/j.dci.2013.05.014. Link to article on publisher's site
    DOI
    10.1016/j.dci.2013.05.014
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34935
    PubMed ID
    23721820
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.dci.2013.05.014
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