The Drosophila IMD pathway in the activation of the humoral immune response
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UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2014-01-01
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The IMD pathway signaling plays a pivotal role in the Drosophila defense against bacteria. During the last two decades, significant progress has been made in identifying the components and deciphering the molecular mechanisms underlying this pathway, including the means of bacterial sensing and signal transduction. While these findings have contributed to the understanding of the immune signaling in insects, they have also provided new insights in studying the mammalian NF-kappaB signaling pathways. Here, we summarize the current view of the IMD pathway focusing on how it regulates the humoral immune response of Drosophila.Source
Kleino A, Silverman N. The Drosophila IMD pathway in the activation of the humoral immune response. Dev Comp Immunol. 2014 Jan;42(1):25-35. doi:10.1016/j.dci.2013.05.014. Link to article on publisher's siteDOI
10.1016/j.dci.2013.05.014Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34935PubMed ID
23721820Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.dci.2013.05.014