Long non-coding RNAs and control of gene expression in the immune system
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UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and Immunology, Program in Innate ImmunityDocument Type
Journal ArticlePublication Date
2014-11-01Keywords
Genetic ProcessesImmunity
Immunology and Infectious Disease
Immunology of Infectious Disease
Infectious Disease
Molecular Biology
Molecular Genetics
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Show full item recordAbstract
All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNAs), have emerged as important regulators of gene expression in diverse biological contexts. lncRNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability, or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell type-specific expression, and their versatile molecular functions is rapidly progressing in all areas of biology. We discuss here these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.Source
Trends Mol Med. 2014 Nov;20(11):623-631. doi: 10.1016/j.molmed.2014.09.002. Epub 2014 Sep 25. Link to article on publisher's siteDOI
10.1016/j.molmed.2014.09.002Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34941PubMed ID
25262537Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.molmed.2014.09.002