Citrobacter rodentium: infection, inflammation and the microbiota
AuthorsCollins, James W.
Keeney, Kristie M.
Crepin, Valerie F.
Rathinam, Vijay A. K.
Fitzgerald, Katherine A.
Finlay, B. Brett
UMass Chan AffiliationsDepartment of Medicine, Division of Infectious Diseases and Immunology
Document TypeJournal Article
Enterohemorrhagic Escherichia coli
Enteropathogenic Escherichia coli
Immunology and Infectious Disease
Immunology of Infectious Disease
MetadataShow full item record
AbstractCitrobacter rodentium is a mucosal pathogen of mice that shares several pathogenic mechanisms with enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC), which are two clinically important human gastrointestinal pathogens. Thus, C. rodentium has long been used as a model to understand the molecular basis of EPEC and EHEC infection in vivo. In this Review, we discuss recent studies in which C. rodentium has been used to study mucosal immunology, including the deregulation of intestinal inflammatory responses during bacteria-induced colitis and the role of the intestinal microbiota in mediating resistance to colonization by enteric pathogens. These insights should help to elucidate the roles of mucosal inflammatory responses and the microbiota in the virulence of enteric pathogens.
SourceNat Rev Microbiol. 2014 Sep;12(9):612-23. doi: 10.1038/nrmicro3315. Epub 2014 Aug 4. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/34944
Related ResourcesLink to Article in PubMed