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    Citrobacter rodentium: infection, inflammation and the microbiota

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    Authors
    Collins, James W.
    Keeney, Kristie M.
    Crepin, Valerie F.
    Rathinam, Vijay A. K.
    Fitzgerald, Katherine A.
    Finlay, B. Brett
    Frankel, Gad
    UMass Chan Affiliations
    Department of Medicine, Division of Infectious Diseases and Immunology
    Document Type
    Journal Article
    Publication Date
    2014-09-01
    Keywords
    Animals
    Citrobacter rodentium
    Colitis
    Colon
    Diet
    Enterobacteriaceae Infections
    Enterohemorrhagic Escherichia coli
    Enteropathogenic Escherichia coli
    Epithelium
    *Host-Pathogen Interactions
    Immunity, Mucosal
    Intestine, Large
    Mice
    *Microbiota
    Signal Transduction
    Virulence
    Bacteria
    Digestive System
    Immunity
    Immunology and Infectious Disease
    Immunology of Infectious Disease
    Infectious Disease
    Pathogenic Microbiology
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    Link to Full Text
    http://dx.doi.org/10.1038/nrmicro3315
    Abstract
    Citrobacter rodentium is a mucosal pathogen of mice that shares several pathogenic mechanisms with enteropathogenic Escherichia coli (EPEC) and enterohaemorrhagic E. coli (EHEC), which are two clinically important human gastrointestinal pathogens. Thus, C. rodentium has long been used as a model to understand the molecular basis of EPEC and EHEC infection in vivo. In this Review, we discuss recent studies in which C. rodentium has been used to study mucosal immunology, including the deregulation of intestinal inflammatory responses during bacteria-induced colitis and the role of the intestinal microbiota in mediating resistance to colonization by enteric pathogens. These insights should help to elucidate the roles of mucosal inflammatory responses and the microbiota in the virulence of enteric pathogens.
    Source
    Nat Rev Microbiol. 2014 Sep;12(9):612-23. doi: 10.1038/nrmicro3315. Epub 2014 Aug 4. Link to article on publisher's site
    DOI
    10.1038/nrmicro3315
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34944
    PubMed ID
    25088150
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1038/nrmicro3315
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