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Recognition of cytosolic DNA by cGAS and other STING-dependent sensors

dc.contributor.authorBhat, Numana
dc.contributor.authorFitzgerald, Katherine A.
dc.date2022-08-11T08:09:08.000
dc.date.accessioned2022-08-23T16:19:04Z
dc.date.available2022-08-23T16:19:04Z
dc.date.issued2014-03-01
dc.date.submitted2014-11-26
dc.identifier.citationEur J Immunol. 2014 Mar;44(3):634-40. doi: 10.1002/eji.201344127. Epub 2014 Jan 13. <a href="http://dx.doi.org/10.1002/eji.201344127">Link to article on publisher's site</a>
dc.identifier.issn0014-2980 (Linking)
dc.identifier.doi10.1002/eji.201344127
dc.identifier.pmid24356864
dc.identifier.urihttp://hdl.handle.net/20.500.14038/34960
dc.description.abstractThe presence of DNA in the cytoplasm of mammalian cells is perceived as a danger signal, alerting the host to the presence of microbial infection. In response to the detection of cytoplasmic DNA, the immune system mounts a programed response that involves the transcription of anti-viral genes such as type I interferons and production of inflammatory cytokines such as IL-1beta. The recent discovery of the cGAS-cGAMP second messenger pathway as well as IFI16 and additional sensors collectively provide critical insights into the molecular basis behind the sensing of cytoplasmic DNA. The insights obtained from these important discoveries could unveil new avenues to understand host-immunity, improve vaccine adjuvancy, and allow development of new treatments for inflammatory diseases associated with abberrant sensing of DNA.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=24356864&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1002/eji.201344127
dc.subjectAnimals
dc.subjectCytosol
dc.subjectDEAD-box RNA Helicases
dc.subjectDNA
dc.subjectHumans
dc.subjectMembrane Proteins
dc.subjectMice
dc.subjectNuclear Proteins
dc.subjectNucleotidyltransferases
dc.subjectProtein Binding
dc.subjectProtein Transport
dc.subjectImmunity
dc.subjectImmunology and Infectious Disease
dc.subjectImmunology of Infectious Disease
dc.subjectInfectious Disease
dc.subjectMolecular Biology
dc.titleRecognition of cytosolic DNA by cGAS and other STING-dependent sensors
dc.typeJournal Article
dc.source.journaltitleEuropean journal of immunology
dc.source.volume44
dc.source.issue3
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/infdis_pp/181
dc.identifier.contextkey6399378
html.description.abstract<p>The presence of DNA in the cytoplasm of mammalian cells is perceived as a danger signal, alerting the host to the presence of microbial infection. In response to the detection of cytoplasmic DNA, the immune system mounts a programed response that involves the transcription of anti-viral genes such as type I interferons and production of inflammatory cytokines such as IL-1beta. The recent discovery of the cGAS-cGAMP second messenger pathway as well as IFI16 and additional sensors collectively provide critical insights into the molecular basis behind the sensing of cytoplasmic DNA. The insights obtained from these important discoveries could unveil new avenues to understand host-immunity, improve vaccine adjuvancy, and allow development of new treatments for inflammatory diseases associated with abberrant sensing of DNA.</p>
dc.identifier.submissionpathinfdis_pp/181
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology, Program in Innate Immunity
dc.source.pages634-40


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