Antiviral autophagy restrictsRift Valley fever virus infection and is conserved from flies to mammals
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Authors
Moy, Ryan H.Gold, Beth
Molleston, Jerome M.
Schad, Veronica
Yanger, Kilangsungla
Salzano, Mary-Virginia
Yagi, Yoshimasa
Fitzgerald, Katherine A
Stanger, Ben Z.
Soldan, Samantha S.
Cherry, Sara
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyDocument Type
Journal ArticlePublication Date
2014-01-16Keywords
Allyl CompoundsAnimals
Antiviral Agents
Autophagy
Cells, Cultured
Drosophila
Evolution, Molecular
Hepatocytes
Humans
Infection Control
Mammals
Mice
Myeloid Differentiation Factor 88
Neurons
Quinazolines
Rats
Rift Valley Fever
Rift Valley fever virus
Toll-Like Receptor 7
Virus Replication
Cells
Immunity
Immunology and Infectious Disease
Immunology of Infectious Disease
Infectious Disease
Parasitic Diseases
Virus Diseases
Viruses
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Show full item recordAbstract
Autophagy has been implicated as a component of host defense, but the significance of antimicrobial autophagy in vivo and the mechanism by which it is regulated during infection are poorly defined. Here we found that antiviral autophagy was conserved in flies and mammals during infection with Rift Valley fever virus (RVFV), a mosquito-borne virus that causes disease in humans and livestock. In Drosophila, Toll-7 limited RVFV replication and mortality through activation of autophagy. RVFV infection also elicited autophagy in mouse and human cells, and viral replication was increased in the absence of autophagy genes. The mammalian Toll-like receptor adaptor, MyD88, was required for anti-RVFV autophagy, revealing an evolutionarily conserved requirement for pattern-recognition receptors in antiviral autophagy. Pharmacologic activation of autophagy inhibited RVFV infection in mammalian cells, including primary hepatocytes and neurons. Thus, autophagy modulation might be an effective strategy for treating RVFV infection, which lacks approved vaccines and therapeutics.Source
Immunity. 2014 Jan 16;40(1):51-65. doi: 10.1016/j.immuni.2013.10.020. Epub 2013 Dec 26. Link to article on publisher's siteDOI
10.1016/j.immuni.2013.10.020Permanent Link to this Item
http://hdl.handle.net/20.500.14038/34965PubMed ID
24374193Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.immuni.2013.10.020
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