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    Mechanisms of inflammasome activation: recent advances and novel insights

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    Authors
    Vanaja, Sivapriya K.
    Rathinam, Vijay A. K.
    Fitzgerald, Katherine A.
    UMass Chan Affiliations
    Department of Medicine, Division of Infectious Diseases and Immunology, Program in Innate Immunity
    Document Type
    Journal Article
    Publication Date
    2015-05-01
    Keywords
    Biochemistry
    Immunity
    Immunology and Infectious Disease
    Immunology of Infectious Disease
    
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    Link to Full Text
    http://dx.doi.org/10.1016/j.tcb.2014.12.009
    Abstract
    Inflammasomes are cytosolic multiprotein platforms assembled in response to invading pathogens and other danger signals. Typically inflammasome complexes contain a sensor protein, an adaptor protein, and a zymogen - procaspase-1. Formation of inflammasome assembly results in processing of inactive procaspase-1 into an active cysteine-protease enzyme, caspase-1, which subsequently activates the proinflammatory cytokines, interleukins IL-1beta and IL-18, and induces pyroptosis, a highly-pyrogenic inflammatory form of cell death. Studies over the past year have unveiled exciting new players and regulatory pathways that are involved in traditional inflammasome signaling, some of them even challenging the existing dogma. This review outlines these new insights in inflammasome research and discusses areas that warrant further exploration.
    Source
    Trends Cell Biol. 2015 May;25(5):308-315. doi: 10.1016/j.tcb.2014.12.009. Link to article on publisher's site
    DOI
    10.1016/j.tcb.2014.12.009
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34971
    PubMed ID
    25639489
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.tcb.2014.12.009
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