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    Immunoprophylaxis against klebsiella and pseudomonas aeruginosa infections. The Federal Hyperimmune Immunoglobulin Trial Study Group

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    Authors
    Donta, Sam T.
    Ellison, Richard T. III
    Federal Hyperimmune Immunoglobulin Trial Study Group
    UMass Chan Affiliations
    Department of Medicine, Division of Infectious Diseases and Immunology
    Document Type
    Journal Article
    Publication Date
    1996-09-01
    Keywords
    Antibodies, Bacterial
    Double-Blind Method
    Humans
    *Immunization, Passive
    Immunoglobulins, Intravenous
    Immunotoxins
    Klebsiella
    Klebsiella Infections
    O Antigens
    Polysaccharides, Bacterial
    Pseudomonas Infections
    Pseudomonas aeruginosa
    Bacterial Infections and Mycoses
    Immunoprophylaxis and Therapy
    Infectious Disease
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    Link to Full Text
    http://dx.doi.org/10.1093/infdis/174.3.537
    Abstract
    To determine if passive immunization could decrease the incidence or severity of Klebsiella and Pseudomonas aeruginosa infections, patients admitted to intensive care units of 16 Department of Veterans Affairs and Department of Defense hospitals were randomized to receive either 100 mg/kg intravenous hyperimmune globulin (IVIG), derived from donors immunized with a 24-valent Klebsiella capsular polysaccharide plus an 8-valent P. aeruginosa O-polysaccharide-toxin A conjugate vaccine, or an albumin placebo. The overall incidence and severity of vaccine-specific Klebsiella plus Pseudomonas infections were not significantly different between the groups receiving albumin and IVIG. There was some evidence that IVIG may decrease the incidence (2.7% albumin vs. 1.2% IVIG) and severity (1.0% vs. 0.3%) of vaccine-specific Klebsiella infections, but these reductions were not statistically significant. The trial was stopped because it was statistically unlikely that IVIG would be protective against Pseudomonas infections at the dosage being used. Patients receiving IVIG had more adverse reactions (14.4% vs. 9.2%).
    Source
    J Infect Dis. 1996 Sep;174(3):537-43. doi: 10.1093/infdis/174.3.537
    DOI
    10.1093/infdis/174.3.537
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/34983
    PubMed ID
    8769611
    Notes

    Full author list omitted for brevity. For the full list of authors, see article.

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    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1093/infdis/174.3.537
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