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dc.contributor.authorRiester, K. A.
dc.contributor.authorPeduzzi, P.
dc.contributor.authorHolford, T. R.
dc.contributor.authorEllison, Richard T. III
dc.contributor.authorDonta, S. T.
dc.date2022-08-11T08:09:09.000
dc.date.accessioned2022-08-23T16:19:11Z
dc.date.available2022-08-23T16:19:11Z
dc.date.issued1997-11-01
dc.date.submitted2015-12-07
dc.identifier.citationJ Clin Epidemiol. 1997 Nov;50(11):1273-9. doi:10.1016/S0895-4356(97)00180-7
dc.identifier.issn0895-4356 (Linking)
dc.identifier.doi10.1016/S0895-4356(97)00180-7
dc.identifier.pmid9393383
dc.identifier.urihttp://hdl.handle.net/20.500.14038/34984
dc.description.abstractStress gastritis is a serious problem in the intensive care unit population. The recent discovery of the causal nature of Helicobacter pylori (H. pylori) in the development of gastric ulcers led us to examine its relationship with stress gastritis. We investigated this relationship in 874 veterans admitted to intensive care units who were tested for the presence of H. pylori and followed for 6 weeks for the development of stress gastritis. We fit spline models to assess functional relationships and used the logistic model to determine the association between H. pylori and stress gastritis. The predictive ability of the model was assessed with receiver operating characteristic (ROC) curve analysis and validated with the bootstrapping technique. Increased anti-H. pylori immunoglobulin A concentrations were found to be an important predictor of stress gastritis independent of other known risk factors.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=9393383&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/S0895-4356(97)00180-7
dc.subjectAged
dc.subjectAntibodies, Bacterial
dc.subjectEnzyme-Linked Immunosorbent Assay
dc.subjectFemale
dc.subjectGastritis
dc.subjectGastrointestinal Hemorrhage
dc.subjectHelicobacter Infections
dc.subjectHelicobacter pylori
dc.subjectHumans
dc.subjectImmunoglobulin A
dc.subjectImmunoglobulin G
dc.subjectIntensive Care Units
dc.subjectLogistic Models
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectROC Curve
dc.subjectRisk Factors
dc.subjectStress, Psychological
dc.subjectBacterial Infections and Mycoses
dc.subjectClinical Epidemiology
dc.subjectDigestive System Diseases
dc.subjectInfectious Disease
dc.titleStatistical evaluation of the role of Helicobacter pylori in stress gastritis: applications of splines and bootstrapping to the logistic model
dc.typeJournal Article
dc.source.journaltitleJournal of clinical epidemiology
dc.source.volume50
dc.source.issue11
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/infdis_pp/204
dc.identifier.contextkey7910519
html.description.abstract<p>Stress gastritis is a serious problem in the intensive care unit population. The recent discovery of the causal nature of Helicobacter pylori (H. pylori) in the development of gastric ulcers led us to examine its relationship with stress gastritis. We investigated this relationship in 874 veterans admitted to intensive care units who were tested for the presence of H. pylori and followed for 6 weeks for the development of stress gastritis. We fit spline models to assess functional relationships and used the logistic model to determine the association between H. pylori and stress gastritis. The predictive ability of the model was assessed with receiver operating characteristic (ROC) curve analysis and validated with the bootstrapping technique. Increased anti-H. pylori immunoglobulin A concentrations were found to be an important predictor of stress gastritis independent of other known risk factors.</p>
dc.identifier.submissionpathinfdis_pp/204
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.source.pages1273-9


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