Elucidating the role of T cells in protection against and pathogenesis of dengue virus infections
UMass Chan Affiliations
Division of Infectious Diseases and Immunology, Department of MedicineDocument Type
Journal ArticlePublication Date
2014-04-24Keywords
dengueimmune response
immunopathology
nonstructural proteins
primary infection
secondary infection
T lymphocyte
vaccine
Immunity
Immunology and Infectious Disease
Immunology of Infectious Disease
Infectious Disease
Microbiology
Metadata
Show full item recordAbstract
Dengue viruses (DENV) cause significantly more human disease than any other arbovirus, with hundreds of thousands of cases leading to severe disease in thousands annually. Antibodies and T cells induced by primary infection with DENV have the potential for both positive (protective) and negative (pathological) effects during subsequent DENV infections. In this review, we summarize studies that have examined T-cell responses in humans following natural infection and vaccination. We discuss studies that support a role for T cells in protection against and those that support a role for the involvement of T cells in the pathogenesis of severe disease. The mechanisms that lead to severe disease are complex, and T-cell responses are an important component that needs to be further evaluated for the development of safe and efficacious DENV vaccines.Source
Future Microbiol. 2014;9(3):411-25. doi: 10.2217/fmb.13.171. Link to article on publisher's siteDOI
10.2217/fmb.13.171Permanent Link to this Item
http://hdl.handle.net/20.500.14038/35011PubMed ID
24762312Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.2217/fmb.13.171