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    Comparison of complement dependent lytic, hemagglutination inhibition and microneutralization antibody responses in influenza vaccinated individuals

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    Authors
    Co, Mary Dawn T.
    Cruz, John
    Takeda, Akira
    Ennis, Francis A.
    Terajima, Masanori
    UMass Chan Affiliations
    Division of Infectious Diseases and Immunology, Department of Medicine
    Document Type
    Journal Article
    Publication Date
    2012-09-01
    Keywords
    Immunity
    Immunology and Infectious Disease
    Immunology of Infectious Disease
    Infectious Disease
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3579901/
    Abstract
    Virus specific, non-neutralizing antibodies such as complement dependent lytic (CDL) antibodies may reduce morbidity following infection through the clearance of infectious virus particles and infected cells. We examined hemagglutination inhibition (HAI), microneutralization (MN) and CDL antibody titers to influenza A H1 and H3 virus strains in 23 healthy young adults who received the 2005-2006 trivalent inactivated influenza vaccine. Post vaccination, we detected statistically significant increases in MN and CDL antibodies but not in HAI antibodies. Statistically significantly higher fold increases in CDL antibodies post vaccination were seen compared with MN and HAI antibodies post vaccination. However, the overall fold increases were modest, likely related to the fact that most of the subjects had received influenza vaccination previously. This study showed that influenza vaccination is not only capable of increasing the level of antibodies that neutralize virus but also antibodies that can cause lysis of infected cells. The biological significance of these CDL antibodies merits further investigation in clinical studies.
    Source
    Hum Vaccin Immunother. 2012 Sep;8(9):1218-22. doi: 10.4161/hv.21025. Epub 2012 Aug 16. Link to article on publisher's site
    DOI
    10.4161/hv.21025
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/35016
    PubMed ID
    22894961
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.4161/hv.21025
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