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dc.contributor.authorTerajima, Masanori
dc.contributor.authorEnnis, Francis A.
dc.date2022-08-11T08:09:09.000
dc.date.accessioned2022-08-23T16:19:19Z
dc.date.available2022-08-23T16:19:19Z
dc.date.issued2011-07-01
dc.date.submitted2017-08-04
dc.identifier.citationViruses. 2011 Jul;3(7):1059-73. doi: 10.3390/v3071059. Epub 2011 Jul 6. <a href="https://doi.org/10.3390/v3071059">Link to article on publisher's site</a>
dc.identifier.issn1999-4915 (Linking)
dc.identifier.doi10.3390/v3071059
dc.identifier.pmid21994770
dc.identifier.urihttp://hdl.handle.net/20.500.14038/35020
dc.description.abstractWe previously hypothesized that increased capillary permeability observed in both hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS) may be caused by hantavirus-specific cytotoxic T cells attacking endothelial cells presenting viral antigens on their surface based on clinical observations and in vitro experiments. In HCPS, hantavirus-specific T cell responses positively correlated with disease severity. In HFRS, in one report, contrary to HCPS, T cell responses negatively correlated with disease severity, but in another report the number of regulatory T cells, which are thought to suppress T cell responses, negatively correlated with disease severity. In rat experiments, in which hantavirus causes persistent infection, depletion of regulatory T cells helped infected rats clear virus without inducing immunopathology. These seemingly contradictory findings may suggest delicate balance in T cell responses between protection and immunopathogenesis. Both too strong and too weak T cell responses may lead to severe disease. It is important to clarify the role of T cells in these diseases for better treatment (whether to suppress T cell functions) and protection (vaccine design) which may need to take into account viral factors and the influence of HLA on T cell responses.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=21994770&dopt=Abstract">Link to Article in PubMed</a>
dc.rights© 2011 by the authors; licensee MDPI, Basel, Switzerland.
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/
dc.subjectCD8+ T cell
dc.subjectendothelial cell
dc.subjecthantavirus
dc.subjecthantavirus cardiopulmonary syndrome
dc.subjecthemorrhagic fever with renal syndrome
dc.subjectimmunopathogenesis
dc.subjectregulatory T cell
dc.subjectImmunity
dc.subjectImmunology and Infectious Disease
dc.subjectImmunology of Infectious Disease
dc.subjectInfectious Disease
dc.titleT cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic fever with renal syndrome
dc.typeJournal Article
dc.source.journaltitleViruses
dc.source.volume3
dc.source.issue7
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1236&amp;context=infdis_pp&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/infdis_pp/237
dc.identifier.contextkey10542751
refterms.dateFOA2022-08-23T16:19:19Z
html.description.abstract<p>We previously hypothesized that increased capillary permeability observed in both hantavirus cardiopulmonary syndrome (HCPS) and hemorrhagic fever with renal syndrome (HFRS) may be caused by hantavirus-specific cytotoxic T cells attacking endothelial cells presenting viral antigens on their surface based on clinical observations and in vitro experiments. In HCPS, hantavirus-specific T cell responses positively correlated with disease severity. In HFRS, in one report, contrary to HCPS, T cell responses negatively correlated with disease severity, but in another report the number of regulatory T cells, which are thought to suppress T cell responses, negatively correlated with disease severity. In rat experiments, in which hantavirus causes persistent infection, depletion of regulatory T cells helped infected rats clear virus without inducing immunopathology. These seemingly contradictory findings may suggest delicate balance in T cell responses between protection and immunopathogenesis. Both too strong and too weak T cell responses may lead to severe disease. It is important to clarify the role of T cells in these diseases for better treatment (whether to suppress T cell functions) and protection (vaccine design) which may need to take into account viral factors and the influence of HLA on T cell responses.</p>
dc.identifier.submissionpathinfdis_pp/237
dc.contributor.departmentDivision of Infectious Diseases and Immunology, Department of Medicine
dc.contributor.departmentCenter for Infectious Disease and Vaccine Research
dc.source.pages1059-73


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© 2011 by the authors; licensee MDPI, Basel, Switzerland.
Except where otherwise noted, this item's license is described as © 2011 by the authors; licensee MDPI, Basel, Switzerland.