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    Sequential immunization with heterologous chimeric flaviviruses induces broad-spectrum cross-reactive CD8+ T cell responses

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    Authors
    Singh, Rekha
    Rothman, Alan L.
    Potts, James A.
    Guirakhoo, Farshad
    Ennis, Francis A.
    Green, Sharone
    UMass Chan Affiliations
    Division of Infectious Diseases and Immunology, Department of Medicine
    Center for Infectious Disease and Vaccine Research
    Document Type
    Journal Article
    Publication Date
    2010-07-15
    Keywords
    Immunity
    Immunology and Infectious Disease
    Immunology of Infectious Disease
    Infectious Disease
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2903744/
    Abstract
    Flavivirus vaccines based on ChimeriVax technology contain the nonstructural genes of the yellow fever vaccine and the premembrane and envelope genes of heterologous flaviviruses, such as Japanese encephalitis and West Nile viruses. These chimeric vaccines induce both humoral and cell-mediated immunity. Mice were vaccinated with yellow fever, chimeric Japanese encephalitis virus (YF/JE), or chimeric West Nile virus (YF/WN) vaccines, followed by a secondary homologous or heterologous vaccination; the hierarchy and function of CD8(+) T cell responses to a variable envelope epitope were then analyzed and compared with those directed against a conserved immunodominant yellow fever virus NS3 epitope. Sequential vaccination with heterologous chimeric flaviviruses generated a broadly cross-reactive CD8(+) T cell response dependent on both the sequence of infecting viruses and epitope variant. The enhanced responses to variant epitopes after heterologous vaccination were not related to preexisting antibody or to higher virus titers. These results demonstrate that the sequence of vaccination affects the expansion of cross-reactive CD8(+) T cells after heterologous chimeric flavivirus challenge.
    Source
    J Infect Dis. 2010 Jul 15;202(2):223-33. doi: 10.1086/653486. Link to article on publisher's site
    DOI
    10.1086/653486
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/35025
    PubMed ID
    20536361
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1086/653486
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