Immunological memory after exposure to variola virus, monkeypox virus, and vaccinia virus
Authors
Sivapalasingam, SumathiKennedy, Jeffrey S.
Borkowsky, William
Valentine, Fred
Zhan, Ming-Xia
Pazoles, Pamela P.
Paolino, Anna
Ennis, Francis A.
Steigbigel, Neal H.
UMass Chan Affiliations
Center for Infectious Disease and Vaccine ResearchDepartment of Medicine, Division of Infectious Diseases and Immunology
Document Type
Journal ArticlePublication Date
2007-04-15Keywords
ImmunityImmunology and Infectious Disease
Immunology of Infectious Disease
Infectious Disease
Metadata
Show full item recordAbstract
We compared cellular and humoral immunity to vaccinia virus (VV) in individuals exposed to 3 different orthopoxviruses: 154 individuals previously vaccinated with VV, 7 individuals with a history of monkeypox virus infection, and 8 individuals with a history of variola virus infection. Among individuals vaccinated > 20 years prior, 9 (14%) of 66 individuals demonstrated VV-specific interferon (IFN)- gamma enzyme-linked immunospot (ELISPOT) assay responses; 21 (50%) of 42 had lymphoproliferative (LP) responses, and 29 (97%) of 30 had VV-specific neutralizing antibodies. One year after monkeypox virus infection, 6 of 7 individuals had IFN- gamma ELISPOT responses, all had VV-specific LP responses, and 3 of 7 had VV-specific neutralizing antibodies. Of 8 individuals with a history of variola virus infection, 1 had a VV-specific IFN- gamma ELISPOT response, 4 had LP responses against whole VV, 7 had LP responses against heat-denatured vaccinia antigen, and 7 had VV-specific neutralizing antibodies. Survivors of variola virus infection demonstrated VV-specific CD4 memory cell responses and neutralizing antibodies > 40 years after infection.Source
J Infect Dis. 2007 Apr 15;195(8):1151-9. Epub 2007 Mar 5. DOI: 10.1086/512161 Link to article on publisher's siteDOI
10.1086/512161Permanent Link to this Item
http://hdl.handle.net/20.500.14038/35041PubMed ID
17357051Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1086/512161