Cellular immune activation in children with acute dengue virus infections is modulated by apoptosis
Authors
Myint, Khin S.Endy, Timothy P.
Mongkolsirichaikul, Duangrat
Manomuth, Choompun
Kalayanarooj, Siripen
Vaughn, David W.
Nisalak, Ananda
Green, Sharone
Rothman, Alan L.
Ennis, Francis A.
Libraty, Daniel H.
UMass Chan Affiliations
Center for Infectious Disease and Vaccine ResearchDepartment of Medicine, Division of Infectious Diseases and Immunology
Document Type
Journal ArticlePublication Date
2006-09-01Keywords
ImmunityImmunology and Infectious Disease
Immunology of Infectious Disease
Infectious Disease
Metadata
Show full item recordAbstract
Apoptosis is an important modulator of cellular immune responses during systemic viral infections. Peripheral-blood mononuclear cell (PBMC) apoptosis and plasma soluble levels of CD95, a mediator of apoptosis, were determined in sequential samples from children participating in a prospective study of dengue virus (DV) infections. During the period of defervescence, levels of PBMC apoptosis were higher in children developing dengue hemorrhagic fever (DHF), the most severe form of illness, than in those with dengue fever (DF) and other, nondengue, febrile illnesses. CD8(+) T lymphocytes made up approximately half of the peak circulating apoptotic PBMCs in DHF and DF. Maximum plasma levels of soluble CD95 were also higher in children with DHF than in those with DF. The level of PBMC apoptosis correlated with dengue disease severity. Apoptosis appears to be involved in modulation of the innate and adaptive immune responses to DV infection and is likely involved in the evolution of immune responses in other viral hemorrhagic fevers.Source
J Infect Dis. 2006 Sep 1;194(5):600-7. Epub 2006 Jul 31. DOI: 10.1086/506451 Link to article on publisher's siteDOI
10.1086/506451Permanent Link to this Item
http://hdl.handle.net/20.500.14038/35044PubMed ID
16897658Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1086/506451