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dc.contributor.authorMaeda, Ken
dc.contributor.authorWest, Kim
dc.contributor.authorHayasaka, Daisuke
dc.contributor.authorEnnis, Francis A.
dc.contributor.authorTerajima, Masanori
dc.date2022-08-11T08:09:09.000
dc.date.accessioned2022-08-23T16:19:26Z
dc.date.available2022-08-23T16:19:26Z
dc.date.issued2005-12-16
dc.date.submitted2017-08-22
dc.identifier.citationViral Immunol. 2005;18(4):657-67. <a href="https://doi.org/10.1089/vim.2005.18.657">Link to article on publisher's site</a>
dc.identifier.issn0882-8245 (Linking)
dc.identifier.doi10.1089/vim.2005.18.657
dc.identifier.pmid16359232
dc.identifier.urihttp://hdl.handle.net/20.500.14038/35049
dc.description.abstractThe efficiency of prime-boost vaccinations on the induction of T-cell responses to Sin Nombre virus nucleocapsid protein expressed by recombinant vaccinia virus, replication-deficient adenovirus, and plasmid DNA in mice was quantitated by the number of epitope-specific interferon-gamma-producing T cells and cytotoxic T-lymphocyte activity induced. In prime-boost immunizations, all combinations that included the recombinant adenovirus induced a much higher number of epitope-specific interferon-gamma-producing T cells than did other combinations. A single immunization of the recombinant adenovirus was able to induce similarly high levels of epitope-specific interferon-gamma-producing cells, despite the fact that the recombinant adenovirus produces less amount of the Sin Nombre virus nucleocapsid protein.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=16359232&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttps://doi.org/10.1089/vim.2005.18.657
dc.subjectImmunity
dc.subjectImmunology and Infectious Disease
dc.subjectImmunology of Infectious Disease
dc.subjectInfectious Disease
dc.titleRecombinant adenovirus vector vaccine induces stronger cytotoxic T-cell responses than recombinant vaccinia virus vector, plasmid DNA, or a combination of these
dc.typeJournal Article
dc.source.journaltitleViral immunology
dc.source.volume18
dc.source.issue4
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/infdis_pp/263
dc.identifier.contextkey10636638
html.description.abstract<p>The efficiency of prime-boost vaccinations on the induction of T-cell responses to Sin Nombre virus nucleocapsid protein expressed by recombinant vaccinia virus, replication-deficient adenovirus, and plasmid DNA in mice was quantitated by the number of epitope-specific interferon-gamma-producing T cells and cytotoxic T-lymphocyte activity induced. In prime-boost immunizations, all combinations that included the recombinant adenovirus induced a much higher number of epitope-specific interferon-gamma-producing T cells than did other combinations. A single immunization of the recombinant adenovirus was able to induce similarly high levels of epitope-specific interferon-gamma-producing cells, despite the fact that the recombinant adenovirus produces less amount of the Sin Nombre virus nucleocapsid protein.</p>
dc.identifier.submissionpathinfdis_pp/263
dc.contributor.departmentCenter for Infectious Disease and Vaccine Research
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.source.pages657-67


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