Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections
AuthorsLibraty, Daniel H.
Endy, Timothy P.
Houng, Huo-Shu H.
Vaughn, David W.
Ennis, Francis A.
Rothman, Alan L.
UMass Chan AffiliationsDepartment of Medicine, Division of Infectious Diseases and Immunology
Center for Infectious Disease and Vaccine Research
Immunology and Infectious Disease
Immunology of Infectious Disease
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AbstractDengue hemorrhagic fever (DHF), the most severe form of illness following infection with a dengue virus, is characterized by plasma leakage, thrombocytopenia, and hepatic inflammation. The interrelationships among virus burden, immune activation, and development of DHF were examined in 54 children with secondary dengue-3 virus infections participating in a prospective, hospital-based study. DHF was associated with higher mean plasma viremia early in illness and earlier peak plasma interferon-gamma levels. Maximum plasma viremia levels correlated with the degree of plasma leakage and thrombocytopenia. Maximum plasma levels of interleukin (IL)-10 and soluble tumor necrosis factor receptor-II correlated with the degree of thrombocytopenia, independently of viremia levels. Hepatic transaminase elevation correlated with plasma soluble IL-2 receptor levels and not with viremia levels. Quantitative differences in virus burden and host immune responses, and the timing of type 1 cytokine responses, have differing influences on the severity of disease manifestations during secondary dengue-3 virus infections.
SourceJ Infect Dis. 2002 May 1;185(9):1213-21. Epub 2002 Apr 16. doi:10.1086/340365 Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/35069
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