Induction of T lymphocyte responses to dengue virus by a candidate tetravalent live attenuated dengue virus vaccine
AuthorsRothman, Alan L.
Ennis, Francis A.
UMass Chan AffiliationsDepartment of Medicine, Division of Infectious Diseases and Immunology
Center for Infectious Disease and Vaccine Research
Immunology and Infectious Disease
Immunology of Infectious Disease
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AbstractDevelopment of a safe and immunogenic tetravalent dengue virus (DV) vaccine has been designated as a priority by the World Health Organization. We characterized the T cell response to DV induced by a candidate live attenuated tetravalent DV vaccine as part of a phase I study. Proliferation and cytotoxic T lymphocyte (CTL) responses to multiple DV serotypes were detected in six of six and four of four subjects studied, respectively. Proliferation responses were higher to DV serotypes 1 and 3 than to serotypes 2 and 4. CTL responses were higher to DV serotypes 2 and 3 than to serotype 1, and included serotype cross-reactive responses. Production of interferon-gamma, but not IL-4, was observed in response to DV stimulation. This candidate vaccine is immunogenic for both CD4+ and CD8+ T lymphocytes. However, T cell responses to the four DV serotypes were not equivalent, suggesting that the vaccine could be further optimized.
SourceVaccine. 2001 Sep 14;19(32):4694-9. doi:10.1016/S0264-410X(01)00236-5
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/35073
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