Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity
Authors
Vaughn, D. W.Green, Sharone
Kalayanarooj, Siripen
Innis, B. L.
Nimmannitaya, Suchitra
Suntayakorn, Saroj
Endy, Timothy P.
Raengsakulrach, B
Rothman, Alan L.
Ennis, Francis A.
Nisalak, Ananda
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyCenter for Infectious Disease and Vaccine Research
Document Type
Journal ArticlePublication Date
2000-01-01Keywords
ImmunityImmunology and Infectious Disease
Immunology of Infectious Disease
Infectious Disease
Metadata
Show full item recordAbstract
Viremia titers in serial plasma samples from 168 children with acute dengue virus infection who were enrolled in a prospective study at 2 hospitals in Thailand were examined to determine the role of virus load in the pathogenesis of dengue hemorrhagic fever (DHF). The infecting virus serotype was identified for 165 patients (DEN-1, 46 patients; DEN-2, 47 patients; DEN-3, 47 patients, DEN-4, 25 patients). Patients with DEN-2 infections experienced more severe disease than those infected with other serotypes. Eighty-one percent of patients experienced a secondary dengue virus infection that was associated with more severe disease. Viremia titers were determined for 41 DEN-1 and 46 DEN-2 patients. Higher peak titers were associated with increased disease severity for the 31 patients with a peak titer identified (mean titer of 107.6 for those with dengue fever vs. 108.5 for patients with DHF, P=.01). Increased dengue disease severity correlated with high viremia titer, secondary dengue virus infection, and DEN-2 virus type.Source
J Infect Dis. 2000 Jan;181(1):2-9. Link to article on publisher's siteDOI
10.1086/315215Permanent Link to this Item
http://hdl.handle.net/20.500.14038/35076PubMed ID
10608744Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1086/315215