High levels of viremia in patients with the Hantavirus pulmonary syndrome
Authors
Terajima, MasanoriHendershot, John D. III
Kariwa, Hiroaki
Koster, Frederick T.
Hjelle, Brian
Goade, Diane
DeFronzo, Matthew
Ennis, Francis A.
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyCenter for Infectious Disease and Vaccine Research
Document Type
Journal ArticlePublication Date
1999-12-01Keywords
ImmunityImmunology and Infectious Disease
Immunology of Infectious Disease
Infectious Disease
Metadata
Show full item recordAbstract
Hantavirus pulmonary syndrome (HPS) is a rare but acute fulminant disease caused by Sin Nombre virus (SNV). To understand the role of the viral load in the pathogenesis of HPS, the load of virus in the blood of patients with HPS was measured. A quantitative reverse transcription-polymerase chain reaction assay was developed for SNV, because SNV is difficult to grow in cell culture. Thirty-eight samples from 26 patients with HPS were analyzed. Twenty of the 26 initial samples were positive for viral RNA (7 of 9 samples were obtained from patients with fatal cases, and 13 of 17 were obtained from survivors). Mean viral RNA copy numbers were 106.1+/-1.4/mL in positive cases (106.7+/-1.4/mL in fatal cases, 105.8+/-1.3/mL in survivors) and were correlated with peak hematocrit (P < .05) and with the lowest platelet count (P=.05). In 8 survivors who had serial samples obtained, viral RNA copy numbers decreased promptly after resolution of fever.Source
J Infect Dis. 1999 Dec;180(6):2030-4. Link to article on publisher's siteDOI
10.1086/315153Permanent Link to this Item
http://hdl.handle.net/20.500.14038/35077PubMed ID
10558964Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1086/315153