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    Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity

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    Authors
    Green, Sharone
    Vaughn, D. W.
    Kalayanarooj, Siripen
    Nimmannitaya, Suchitra
    Suntayakorn, Saroj
    Nisalak, Ananda
    Lew, Robert
    Innis, B. L.
    Kurane, Ichiro
    Rothman, Alan L.
    Ennis, Francis A.
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    UMass Chan Affiliations
    Center for Infectious Disease and Vaccine Research
    Document Type
    Journal Article
    Publication Date
    1999-04-01
    Keywords
    Immunity
    Immunology and Infectious Disease
    Immunology of Infectious Disease
    Infectious Disease
    
    Metadata
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    Link to Full Text
    https://doi.org/10.1086/314680
    Abstract
    T lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with (sTNFRs) were higher in children who developed DHF than in those with dengue fever (DF) or other nondengue febrile illnesses (OFIs) and were correlated with the degree of subsequent plasma leakage. Soluble CD8 and soluble interleukin-2 receptor levels were also elevated in children with DHF compared with those with DF. Interferon-gamma and sTNFR 60-kDa levels were higher in children with dengue than in those with OFIs. TNF-alpha was detectable more often in DHF than in DF or OFIs (P < .05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted.
    Source
    J Infect Dis. 1999 Apr;179(4):755-62. Link to article on publisher's site
    DOI
    10.1086/314680
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/35083
    PubMed ID
    10068569
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1086/314680
    Scopus Count
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    UMass Chan Faculty and Researcher Publications

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