Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity
Vaughn, D. W.
Innis, B. L.
Rothman, Alan L.
Ennis, Francis A.
UMass Chan AffiliationsCenter for Infectious Disease and Vaccine Research
Document TypeJournal Article
Immunology and Infectious Disease
Immunology of Infectious Disease
MetadataShow full item record
AbstractT lymphocyte activation and increased cytokine levels have been described in retrospective studies of children presenting with dengue hemorrhagic fever (DHF). Serial plasma samples obtained in a prospective study of Thai children presenting with (sTNFRs) were higher in children who developed DHF than in those with dengue fever (DF) or other nondengue febrile illnesses (OFIs) and were correlated with the degree of subsequent plasma leakage. Soluble CD8 and soluble interleukin-2 receptor levels were also elevated in children with DHF compared with those with DF. Interferon-gamma and sTNFR 60-kDa levels were higher in children with dengue than in those with OFIs. TNF-alpha was detectable more often in DHF than in DF or OFIs (P < .05). These results support the hypothesis that immune activation contributes to the pathogenesis of DHF. Further studies evaluating the predictive value of sTNFR80 for DHF are warranted.
SourceJ Infect Dis. 1999 Apr;179(4):755-62. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/35083
Related ResourcesLink to Article in PubMed