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    High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome

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    Authors
    Mori, Masuko
    Rothman, Alan L.
    Kurane, Ichiro
    Montoya, James M.
    Nolte, Kurt B.
    Norman, Joyce E.
    Waite, Douglas C.
    Koster, Frederick T.
    Ennis, Francis A.
    UMass Chan Affiliations
    Department of Medicine, Division of Infectious Diseases and Immunology
    Center for Infectious Disease and Vaccine Research
    Document Type
    Journal Article
    Publication Date
    1999-02-01
    Keywords
    Immunity
    Immunology and Infectious Disease
    Immunology of Infectious Disease
    Infectious Disease
    
    Metadata
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    Link to Full Text
    https://doi.org/10.1086/314597
    Abstract
    Hantavirus pulmonary syndrome (HPS) is characterized by the rapid onset of pulmonary edema and a high case-fatality rate. Hantavirus antigens have been demonstrated in pulmonary capillary endothelial cells, but the mechanisms causing capillary leakage remain unclear. Immunohistochemical staining was used to enumerate cytokine-producing cells (monokines: interleukin [IL]-1alpha, IL-1beta, IL-6, and tumor necrosis factor [TNF]-alpha; lymphokines: interferon-gamma, IL-2, IL-4, and TNF-beta) in tissues obtained at autopsy from subjects with HPS. High numbers of cytokine-producing cells were seen in the lung and spleen tissues of HPS patients, but only low numbers in the livers and kidneys. A modest increase in the numbers of cytokine-producing cells was detected in the lungs of patients who died with non-HPS acute respiratory distress syndrome (ARDS), and very few (or no) cytokine-producing cells were detected in the lungs of patients who died of causes other than ARDS. These results suggest that local cytokine production may play an important role in the pathogenesis of HPS.
    Source
    J Infect Dis. 1999 Feb;179(2):295-302. Link to article on publisher's site
    DOI
    10.1086/314597
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/35085
    PubMed ID
    9878011
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1086/314597
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