High levels of cytokine-producing cells in the lung tissues of patients with fatal hantavirus pulmonary syndrome
Authors
Mori, MasukoRothman, Alan L.
Kurane, Ichiro
Montoya, James M.
Nolte, Kurt B.
Norman, Joyce E.
Waite, Douglas C.
Koster, Frederick T.
Ennis, Francis A.
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyCenter for Infectious Disease and Vaccine Research
Document Type
Journal ArticlePublication Date
1999-02-01Keywords
ImmunityImmunology and Infectious Disease
Immunology of Infectious Disease
Infectious Disease
Metadata
Show full item recordAbstract
Hantavirus pulmonary syndrome (HPS) is characterized by the rapid onset of pulmonary edema and a high case-fatality rate. Hantavirus antigens have been demonstrated in pulmonary capillary endothelial cells, but the mechanisms causing capillary leakage remain unclear. Immunohistochemical staining was used to enumerate cytokine-producing cells (monokines: interleukin [IL]-1alpha, IL-1beta, IL-6, and tumor necrosis factor [TNF]-alpha; lymphokines: interferon-gamma, IL-2, IL-4, and TNF-beta) in tissues obtained at autopsy from subjects with HPS. High numbers of cytokine-producing cells were seen in the lung and spleen tissues of HPS patients, but only low numbers in the livers and kidneys. A modest increase in the numbers of cytokine-producing cells was detected in the lungs of patients who died with non-HPS acute respiratory distress syndrome (ARDS), and very few (or no) cytokine-producing cells were detected in the lungs of patients who died of causes other than ARDS. These results suggest that local cytokine production may play an important role in the pathogenesis of HPS.Source
J Infect Dis. 1999 Feb;179(2):295-302. Link to article on publisher's siteDOI
10.1086/314597Permanent Link to this Item
http://hdl.handle.net/20.500.14038/35085PubMed ID
9878011Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1086/314597