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    Early clinical and laboratory indicators of acute dengue illness

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    Authors
    Kalayanarooj, S.
    Vaughn, David W.
    Nimmannitaya, Suchitra
    Green, Sharone
    Suntayakorn, S.
    Kunentrasai, N.
    Viramitrachai, W.
    Ratanachu-eke, S.
    Kiatpolpoj, S.
    Innis, B. L.
    Rothman, Alan L.
    Nisalak, Ananda
    Ennis, Francis A.
    Show allShow less
    UMass Chan Affiliations
    Department of Medicine, Division of Infectious Diseases and Immunology
    Center for Infectious Disease and Vaccine Research
    Document Type
    Journal Article
    Publication Date
    1997-08-01
    Keywords
    Immunity
    Immunology and Infectious Disease
    Immunology of Infectious Disease
    Infectious Disease
    
    Metadata
    Show full item record
    Link to Full Text
    https://doi.org/10.1086/514047
    Abstract
    A prospective observational study was conducted to identify early indicators of acute dengue virus infection. Children with fever for < 72 h without obvious cause were studied at hospitals in Bangkok and Kamphaeng Phet, Thailand, until resolution of fever. Of 172 evaluable subjects (91% of enrollees), 60 (35%) had dengue, including 32 with dengue fever (DF) and 28 with dengue hemorrhagic fever (DHF). At enrollment, children with dengue were more likely than children with other febrile illnesses (OFI) to report anorexia, nausea, and vomiting and to have a positive tourniquet test, and they had lower total white blood cell counts, absolute neutrophil and absolute monocyte counts, and higher plasma alanine and aspartate (AST) aminotransferase levels than children with OFI. Plasma AST levels were higher in children who developed DHF than in those with DF. These data identify simple clinical and laboratory parameters that help to identify children with DF or DHF.
    Source
    J Infect Dis. 1997 Aug;176(2):313-21. DOI: 10.1086/514047
    DOI
    10.1086/514047
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/35096
    PubMed ID
    9237695
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1086/514047
    Scopus Count
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