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dc.contributor.authorDharakul, Tararaj
dc.contributor.authorKurane, Ichiro
dc.contributor.authorBhamarapravati, Natth
dc.contributor.authorYoksan, Sutee
dc.contributor.authorVaughn, David W.
dc.contributor.authorHoke, Charles H. Jr
dc.contributor.authorEnnis, Francis A.
dc.date2022-08-11T08:09:10.000
dc.date.accessioned2022-08-23T16:19:41Z
dc.date.available2022-08-23T16:19:41Z
dc.date.issued1994-07-01
dc.date.submitted2017-11-13
dc.identifier.citationJ Infect Dis. 1994 Jul;170(1):27-33.
dc.identifier.issn0022-1899 (Linking)
dc.identifier.pmid7912253
dc.identifier.urihttp://hdl.handle.net/20.500.14038/35109
dc.description.abstractA live attenuated dengue virus type 2 candidate vaccine (16681-PDK53) was evaluated in a phase I trial in 10 nonimmune adult volunteers. The dengue virus-specific memory T cell responses were analyzed as part of this study. Dengue virus-specific T cell proliferative responses were observed in all subjects after stimulating their peripheral blood mononuclear cells with live viruses or noninfectious viral antigens. The highest proliferative response was against dengue virus type 2, although cross-reactivity with other flaviviruses was detected to a lesser degree in some subjects. Dengue virus type 2-specific CD4+ and CD8+ cytotoxic T lymphocytes were generated in all vaccinees. This study investigated whether the candidate vaccine was efficacious in inducing dengue virus-specific CD4+ and CD8+ T cell memory after a single immunization in nonimmune recipients.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=7912253&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://www.jstor.org/stable/30133471
dc.subjectImmunity
dc.subjectImmunology and Infectious Disease
dc.subjectImmunology of Infectious Disease
dc.subjectInfectious Disease
dc.subjectVirology
dc.titleDengue virus-specific memory T cell responses in human volunteers receiving a live attenuated dengue virus type 2 candidate vaccine
dc.typeJournal Article
dc.source.journaltitleThe Journal of infectious diseases
dc.source.volume170
dc.source.issue1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/infdis_pp/319
dc.identifier.contextkey11035657
html.description.abstract<p>A live attenuated dengue virus type 2 candidate vaccine (16681-PDK53) was evaluated in a phase I trial in 10 nonimmune adult volunteers. The dengue virus-specific memory T cell responses were analyzed as part of this study. Dengue virus-specific T cell proliferative responses were observed in all subjects after stimulating their peripheral blood mononuclear cells with live viruses or noninfectious viral antigens. The highest proliferative response was against dengue virus type 2, although cross-reactivity with other flaviviruses was detected to a lesser degree in some subjects. Dengue virus type 2-specific CD4+ and CD8+ cytotoxic T lymphocytes were generated in all vaccinees. This study investigated whether the candidate vaccine was efficacious in inducing dengue virus-specific CD4+ and CD8+ T cell memory after a single immunization in nonimmune recipients.</p>
dc.identifier.submissionpathinfdis_pp/319
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology
dc.contributor.departmentCenter for Infectious Disease and Vaccine Research
dc.source.pages27-33


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