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    Recognition of disparate HA and NS1 peptides by an H-2Kd-restricted, influenza specific CTL clone

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    Authors
    Kuwano, Koichi
    Reyes, Victor E.
    Humphreys, Robert E.
    Ennis, Francis A.
    UMass Chan Affiliations
    Department of Pharmacology and Medicine
    Department of Medicine, Division of Infectious Diseases and Immunology
    Center for Infectious Disease and Vaccine Research
    Document Type
    Journal Article
    Publication Date
    1991-01-01
    Keywords
    Immunity
    Immunology and Infectious Disease
    Immunology of Infectious Disease
    Infectious Disease
    Virology
    
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    Link to Full Text
    https://doi.org/10.1016/0161-5890(91)90080-4
    Abstract
    CTLs (CD8+) are known to recognize exogenous peptide in the context of class I MHC molecules. We observed that an influenza subtype H1 and H2 cross-reactive CTL clone B7, which was stimulated by a fusion protein containing a portion of HA2 subunit of A/PR/8 virus HA, recognized a synthetic peptide (residues 515-526) of the HA2 subunit of A/PR/8 virus strain. This CTL clone also recognized a structurally disparate NS1 peptide 50-68 of the same A/PR/8 virus. We examined the recognition of the NS1 peptide 50-68 and the HA peptide 515-526 by the subcloned CTL clone, B7-B7. Cold target inhibition experiments showed that the recognition of the HA peptide by the CTL clone B7-B7 could be competed by NS1 peptide-treated target cells and vice versa. The recognition of both NS1 peptide and HA peptide by the CTL clone B7-B7 was restricted by the same allele, H2Kd. In addition, this NS1 peptide requires approximately a 600-fold higher concn for optimal CTL recognition than did the HA peptide. We conclude that the TCR on clone B7-B7 recognizes the HA peptide or the NS1 peptide as comparable complexes with the same class I MHC molecules, although there is no obvious homology in the primary sequences of HA 515-526 and NS1 50-68 peptides. CTLs elicited with certain antigens appear to recognize distinctively different antigens complexed to the same presenting MHC molecule.
    Source
    Mol Immunol. 1991 Jan-Feb;28(1-2):1-7.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/35123
    PubMed ID
    1707132
    Related Resources
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    UMass Chan Faculty and Researcher Publications

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