Cross-reactive protection against influenza A virus infections by an NS1-specific CTL clone
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UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and ImmunologyCenter for Infectious Disease and Vaccine Research
Document Type
Journal ArticlePublication Date
1990-09-01Keywords
ImmunityImmunology and Infectious Disease
Immunology of Infectious Disease
Infectious Disease
Virology
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Show full item recordAbstract
An influenza A subtype cross-reactive CTL clone (A-11) was established following stimulation of A/PR/8 virus-immune spleen cells of Balb/C (H-2d) mice. This T cell clone lysed target cells infected with influenza viruses of the H1, H2, or H3 subtypes, and recognizes a conserved epitope on the NS1 protein. The clone is restricted by the H-2Ld allele. Adoptive transfer of A-11 significantly reduced virus titers in the lungs of mice infected with influenza A viruses of the H1, H2, or H3 subtypes. These results suggest that the conserved epitope on NS1 which is recognized by A-11 may be a useful component to consider for inclusion in experimental cross-reactive influenza vaccines.Source
Virology. 1990 Sep;178(1):174-9. doi:10.1016/0042-6822(90)90391-4DOI
10.1016/0042-6822(90)90391-4Permanent Link to this Item
http://hdl.handle.net/20.500.14038/35124PubMed ID
1697125Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/0042-6822(90)90391-4