Show simple item record

dc.contributor.authorErturk Hasdemir, Deniz
dc.contributor.authorPaquette, Nicholas Paul
dc.contributor.authorAggarwal, Kamna
dc.contributor.authorSilverman, Neal S.
dc.date2022-08-11T08:09:10.000
dc.date.accessioned2022-08-23T16:19:51Z
dc.date.available2022-08-23T16:19:51Z
dc.date.issued2007-12-07
dc.date.submitted2009-12-15
dc.identifier.citationIn Holger Heine, Ed. Innate Immunity of Plants, Animals, and Humans. In series: Nucleic Acids and Molecular Biology, Vol. 21, Springer-Verlag Berlin Heidelberg, December 2007. ISBN 978-3-540-73929-6 (Print) 978-3-540-73930-2 (Online). <a href="http://dx.doi.org/10.1007/978-3-540-73930-2_3">Link to article on publisher's website</a>
dc.identifier.doi10.1007/978-3-540-73930-2_3
dc.identifier.urihttp://hdl.handle.net/20.500.14038/35149
dc.description.abstractInsects mount a robust innate immune response against a wide array of microbial pathogens. For example, the fruit fly Drosphila melanogaster uses both cellular and humoral innate immune responses to combat pathogens. The hallmark of the Drosophila humoral immune response is the rapid induction of antimicrobial peptide genes in the fat body, the homolog of the mammalian liver. Expression of these antimicrobial peptide genes is rapidly induced by two immune signaling pathways, which respond to distinct microorganisms. The Toll pathway is activated by fungal and Gram-positive bacterial infections, whereas the IMD pathway responds to Gram-negative bacteria. In this chapter, we discuss recent advances in understanding the mechanisms involved in microbial recogni-tion, signal transduction, and immune protection mediated by these pathways, highlighting similarities and differences between Drosophila immune responses and mammalian innate immunity.
dc.language.isoen_US
dc.relation.urlhttp://dx.doi.org/10.1007/978-3-540-73930-2_3
dc.subjectDrosophila melanogaster
dc.subjectImmunity, Innate
dc.subjectToll-Like Receptors
dc.subjectDrosophila Proteins
dc.subjectImmunology and Infectious Disease
dc.titleBug Versus Bug: Humoral Immune Responses in <em>Drosophila melanogaster</em>
dc.typeBook Chapter
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/infdis_pp/36
dc.identifier.contextkey1089273
html.description.abstract<p>Insects mount a robust innate immune response against a wide array of microbial pathogens. For example, the fruit fly Drosphila melanogaster uses both cellular and humoral innate immune responses to combat pathogens. The hallmark of the Drosophila humoral immune response is the rapid induction of antimicrobial peptide genes in the fat body, the homolog of the mammalian liver. Expression of these antimicrobial peptide genes is rapidly induced by two immune signaling pathways, which respond to distinct microorganisms. The Toll pathway is activated by fungal and Gram-positive bacterial infections, whereas the IMD pathway responds to Gram-negative bacteria. In this chapter, we discuss recent advances in understanding the mechanisms involved in microbial recogni-tion, signal transduction, and immune protection mediated by these pathways, highlighting similarities and differences between Drosophila immune responses and mammalian innate immunity.</p>
dc.identifier.submissionpathinfdis_pp/36
dc.contributor.departmentDepartment of Medicine, Division of Infectious Diseases and Immunology


This item appears in the following Collection(s)

Show simple item record