Macrophages recognize streptococci through bacterial single-stranded RNA
AuthorsDeshmukh, Sachin D.
Golenbock, Douglas T.
UMass Chan AffiliationsDepartment of Medicine, Division of Infectious Diseases and Immunology
Bacterial Infections and Mycoses
Immunology of Infectious Disease
MetadataShow full item record
AbstractGroup B streptococcus (GBS) is a leading cause of both neonatal sepsis and meningitis, two diseases that are characterized by inflammation. However, the manner in which GBS organisms are recognized by monocytes and macrophages is poorly understood. In this study, we report that the recognition of GBS and other Gram-positive bacteria by macrophages and monocytes relies on bacterial single-stranded RNA (ssRNA). ssRNA interacts with a signalling complex, which comprises the Toll-like receptor adaptors MyD88 and UNC-93B, but not the established MyD88-dependent ssRNA sensors. The role of ssRNA in the recognition of Gram-positive bacteria--leading to the induction of inflammatory cytokines--has potential implications for sepsis pathogenesis, diagnosis and treatment.
EMBO Rep. 2011 Jan;12(1):71-6. doi: 10.1038/embor.2010.189. Epub 2010 Dec 17. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/35163