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    NOD1 and NOD2 mediate sensing of periodontal pathogens

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    Authors
    Okugawa, T.
    Kaneko, Takashi
    Yoshimura, A.
    Silverman, Neal S.
    Hara, Y.
    UMass Chan Affiliations
    Department of Medicine, Division of Infectious Diseases and Immunology
    Document Type
    Journal Article
    Publication Date
    2010-02-01
    Keywords
    Actinobacillus actinomycetemcomitans
    Cell Line
    Chronic Periodontitis
    Fusobacterium nucleatum
    Humans
    Immune Evasion
    Interleukin-8
    Kidney
    Lipid A
    NF-kappa B
    Nod1 Signaling Adaptor Protein
    Nod2 Signaling Adaptor Protein
    Peptidoglycan
    Porphyromonas gingivalis
    Immunology and Infectious Disease
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    Link to Full Text
    http://dx.doi.org/10.1177/0022034509354843
    Abstract
    In bacterial infection, Nucleotide-binding Oligomerization Domain (NOD) 1 and NOD2 induce innate immune responses by recognizing fragments of the bacterial component peptidoglycan (PGN). To determine the roles of these receptors in detection of periodontal pathogens, we stimulated human embryonic kidney cells expressing NOD1 or NOD2 with heat-killed Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Fusobacterium nucleatum or their soluble PGNs (sPGNs). All bacteria and their sPGNs could stimulate activation of NF-kappaB. However, there were differences in NOD1- and NOD2-stimulatory activities among the species of bacteria. P. gingivalis showed weaker NOD1- and NOD2-stimulatory activities than did other bacteria. These differences in activities were confirmed by production of interleukin-8 from oral epithelial cells stimulated with sPGNs. These findings indicate that both NOD1 and NOD2 might be involved in the recognition of periodontal pathogens, and that the weak NOD-stimulatory property of P. gingivalis might be helpful for survival in the periodontal pocket.
    Source
    J Dent Res. 2010 Feb;89(2):186-91. Epub 2009 Dec 29. Link to article on publisher's site
    DOI
    10.1177/0022034509354843
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/35169
    PubMed ID
    20040739
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1177/0022034509354843
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    UMass Chan Faculty and Researcher Publications

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