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    Caenorhabditis elegans in high-throughput screens for anti-infective compounds

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    Authors
    Peterson, Nicholas D.
    Pukkila-Worley, Read
    UMass Chan Affiliations
    Program in Innate Immunity, Department of Medicine, Division of Infectious Diseases and Immunology
    Document Type
    Journal Article
    Publication Date
    2018-10-01
    Keywords
    Immunity
    Immunology of Infectious Disease
    Immunopathology
    Infectious Disease
    Microbiology
    
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463281/
    Abstract
    New classes of antimicrobials that are effective therapies for infections with multi-drug resistant pathogens are urgently needed. The nematode Caenorhabditis elegans has been incorporated into small molecule screening platforms to identify anti-infective compounds that provide protection of a host during infection. The use of a live animal in these screening systems offers several advantages, including the ability to identify molecules that boost innate immune responses in a manner advantageous to host survival and compounds that disrupt bacterial virulence mechanisms. In addition, new classes of antimicrobials that target the pathogen have been uncovered, as well as interesting chemical probes that can be used to dissect new mechanisms of host-pathogen interactions.
    Source

    Peterson ND, Pukkila-Worley R. Caenorhabditis elegans in high-throughput screens for anti-infective compounds. Curr Opin Immunol. 2018 Oct;54:59-65. doi: 10.1016/j.coi.2018.06.003. Epub 2018 Jun 20. PMID: 29935375; PMCID: PMC6463281. Link to article on publisher's site

    DOI
    10.1016/j.coi.2018.06.003
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/35201
    PubMed ID
    29935375
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.coi.2018.06.003
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