Catenin' on to nucleic acid sensing

Authors
Rathinam, Vijay A.K.
Sharma, Shrutie
Fitzgerald, Katherine A.
UMass Chan Affiliations
Department of Medicine, Division of Infectious Diseases and Immunology
Document Type
Journal Article
Publication Date
2010-05-21
Keywords
Catenins
Humans
Immunity, Innate
Interferon Regulatory Factor-3
Interferon Type I
Listeria monocytogenes
Protein-Serine-Threonine Kinases
RNA-Binding Proteins
Signal Transduction
Vesicular Stomatitis

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Link to Full Text
http://dx.doi.org/10.1038/ni0610-466
Abstract
Many pathogens induce a type I interferon response via a pathway dependent on the kinase TBK1 and transcription factor IRF3. However, LRRFIP1, a cytosolic sensor of DNA and RNA, triggers interferon production by a β-catenin-dependent signal.
Source
Nat Immunol. 2010 Jun;11(6):466-8. Link to article on publisher's site
DOI
10.1038/ni0610-466
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/35214
PubMed ID
20485273
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