Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome
Bauernfeind, Franz G.
Fitzgerald, Katherine A.
UMass Chan AffiliationsDepartment of Medicine, Division of Infectious Diseases and Immunology
Document TypeJournal Article
Mice, Inbred C57BL
Immunology and Infectious Disease
MetadataShow full item record
AbstractThe inflammasome pathway functions to regulate caspase-1 activation in response to a broad range of stimuli. Caspase-1 activation is required for the maturation of the pivotal pro-inflammatory cytokines of the pro-IL-1beta family. In addition, caspase-1 activation leads to a certain type of cell death known as pyroptosis. Activation of the inflammasome has been shown to play a critical role in the recognition and containment of various microbial pathogens, including the intracellularly replicating Listeria monocytogenes; however, the inflammasome pathways activated during L. monocytogenes infection are only poorly defined. Here, we demonstrate that L. monocytogenes activates both the NLRP3 and the AIM2 inflammasome, with a predominant involvement of the AIM2 inflammasome. In addition, L. monocytogenes-triggered cell death was diminished in the absence of both AIM2 and NLRP3, and is concomitant with increased intracellular replication of L. monocytogenes. Altogether, these data establish a role for DNA sensing through the AIM2 inflammasome in the detection of intracellularly replicating bacteria.
SourceEur J Immunol. 2010 Jun;40(6):1545-51. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/35218
Related ResourcesLink to Article in PubMed