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    Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

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    Authors
    Kim, Sarah
    Bauernfeind, Franz G.
    Ablasser, Andrea
    Hartmann, Gunther
    Fitzgerald, Katherine A.
    Latz, Eicke
    Hornung, Veit
    UMass Chan Affiliations
    Department of Medicine, Division of Infectious Diseases and Immunology
    Document Type
    Journal Article
    Publication Date
    2010-03-25
    Keywords
    Animals
    Carrier Proteins
    Immunoblotting
    Listeria monocytogenes
    Listeriosis
    Macrophages
    Mice
    Mice, Inbred C57BL
    Microscopy, Confocal
    Nuclear Proteins
    Immunology and Infectious Disease
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    Link to Full Text
    http://dx.doi.org/10.1002/eji.201040425
    Abstract
    The inflammasome pathway functions to regulate caspase-1 activation in response to a broad range of stimuli. Caspase-1 activation is required for the maturation of the pivotal pro-inflammatory cytokines of the pro-IL-1beta family. In addition, caspase-1 activation leads to a certain type of cell death known as pyroptosis. Activation of the inflammasome has been shown to play a critical role in the recognition and containment of various microbial pathogens, including the intracellularly replicating Listeria monocytogenes; however, the inflammasome pathways activated during L. monocytogenes infection are only poorly defined. Here, we demonstrate that L. monocytogenes activates both the NLRP3 and the AIM2 inflammasome, with a predominant involvement of the AIM2 inflammasome. In addition, L. monocytogenes-triggered cell death was diminished in the absence of both AIM2 and NLRP3, and is concomitant with increased intracellular replication of L. monocytogenes. Altogether, these data establish a role for DNA sensing through the AIM2 inflammasome in the detection of intracellularly replicating bacteria.
    Source
    Eur J Immunol. 2010 Jun;40(6):1545-51. Link to article on publisher's site
    DOI
    10.1002/eji.201040425
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/35218
    PubMed ID
    20333626
    Related Resources
    Link to Article in PubMed
    ae974a485f413a2113503eed53cd6c53
    10.1002/eji.201040425
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