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    Effect of fibrous glass on rat pleural mesothelium. Histopathologic observations

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    Authors
    Fraire, Armando E.
    Greenberg, S. Donald
    Spjut, Harlan J.
    Roggli, Victor L.
    Dodson, Ronald F.
    Cartwright, Joiner
    Williams, Glenn
    Baker, Stephen P.
    UMass Chan Affiliations
    Department of Pathology
    Department of Cell Biology
    Information Services, Academic Computing Services
    Document Type
    Journal Article
    Publication Date
    1994-08-01
    Keywords
    Adhesions
    Animals
    Epithelium
    Female
    Fibrosis
    Foreign-Body Reaction
    *Glass
    Inflammation
    Mesothelioma
    Pleura
    Pleural Neoplasms
    Rats
    Rats, Inbred F344
    Cancer Biology
    Cell and Developmental Biology
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    Link to Full Text
    http://ajrccm.atsjournals.org/content/150/2/521.long
    Abstract
    Female Fisher 344 rats (n = 25) were inoculated intrapleurally with a single 20-mg dose of (JM-100) fibrous glass. The mean length (2.2 microns) and width (0.15 microns) of the fibrous glass particles was within respirable range. Following inoculation, the rats were killed at timed intervals ranging from 2 to 430 d from inoculation. The pleural histopathologic changes were independently observed by a panel of three pathologists blinded to the time elapsed from inoculation. Fibrous adhesions, nodular lesions, and grossly evident tumor were noted in 15, 2, and 1 rat, respectively. In 1 rat there were combined adhesive and nodular changes, and in 6 there were no grossly detectable abnormalities. Chronic inflammation, fibrosis, and foreign body reaction were found in 9, 18, and 10 rats, respectively. Mesothelial hyperplasia and dysplasia were observed in 16 and 9 rats, respectively. Of 16 rats with the severest degree of hyperplasia and dysplasia, 3 developed malignant mesothelioma. This study suggests that a spectrum of rat pleural mesothelial histopathologic changes occurs before development of mesothelioma. The association of severe dysplasia in 3 rats with fully developed mesothelioma suggests that there may be a gradual progression from mesothelial hyperplasia or dysplasia to mesothelioma. Multivariate analysis further suggests that gross pleural nodular lesions and dysplasia may be significantly associated with the development of mesothelioma in this experimental model.
    Source
    Am J Respir Crit Care Med. 1994 Aug;150(2):521-7.
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/35288
    PubMed ID
    8049840
    Related Resources
    Link to article in PubMed
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    UMass Chan Faculty and Researcher Publications

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