Snf5 tumor suppressor couples chromatin remodeling, checkpoint control, and chromosomal stability
Name:
Publisher version
UMass Chan Affiliations
Department of Cell BiologyDocument Type
Journal ArticlePublication Date
2005-04-20Keywords
AneuploidyAnimals
Cell Cycle
Cell Cycle Proteins
Chromatin Assembly and Disassembly
Chromosomal Instability
Chromosomal Proteins, Non-Histone
Cyclin D1
Cyclin-Dependent Kinase 4
Cyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent KinasesDNA-Binding ProteinsE2F Transcription FactorsHumansModels, BiologicalPhosphorylationPolyploidyProto-Oncogene ProteinsRetinoblastoma ProteinRhabdoid TumorTranscription FactorsTumor Suppressor ProteinsCell Biology
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SNF5 is a core subunit of the SWI/SNF chromatin-remodeling complex. Mammalian SNF5 is essential for normal cell viability, and loss or mutation of the human SNF gene is the molecular basis for familial malignant rhabdoid tumorigenesis. Previous studies have suggested that SNF5 suppresses cancer by signaling through the p16Ink4a and retinoblastoma tumor suppressors to negatively regulate cell cycle progression from G0/G1 into S phase. A recent paper in Genes and Development (Vries et al., 2005) reports that human SNF5 also signals via the p16INK4a-Rb-E2F pathway to regulate chromosomal stability, suggesting a new function for this chromatin remodeling protein in tumor suppression.Source
Cancer Cell. 2005 Apr;7(4):294-5. Link to article on publisher's siteDOI
10.1016/j.ccr.2005.04.001Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36018Related Resources
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