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Measurements of serum mullerian inhibiting substance in the evaluation of children with nonpalpable gonads

dc.contributor.authorLee, Mary M.
dc.contributor.authorDonahoe, Patricia K.
dc.contributor.authorSilverman, B. L.
dc.contributor.authorHasegawa, T.
dc.contributor.authorHasegawa, Yasuhiro
dc.contributor.authorGustafson, M. L.
dc.contributor.authorChang, Y. C.
dc.contributor.authorMacLaughlin, David T.
dc.date2022-08-11T08:09:16.000
dc.date.accessioned2022-08-23T16:24:09Z
dc.date.available2022-08-23T16:24:09Z
dc.date.issued1997-05-22
dc.date.submitted2014-07-10
dc.identifier.citation<p>Lee MM, Donahoe PK, Silverman BL, Hasegawa T, Hasegawa Y, Gustafson ML, Chang YC, MacLaughlin DT. Measurements of serum müllerian inhibiting substance in the evaluation of children with nonpalpable gonads. N Engl J Med. 1997 May 22;336(21):1480-6. doi: 10.1056/NEJM199705223362102. PMID: 9154766. <a href="http://dx.doi.org/10.1056/NEJM199705223362102">Link to article on publisher's site</a></p>
dc.identifier.issn0028-4793 (Linking)
dc.identifier.doi10.1056/NEJM199705223362102
dc.identifier.pmid9154766
dc.identifier.urihttp://hdl.handle.net/20.500.14038/36061
dc.description<p>At the time of publication, Mary Lee was not yet affiliated with the University of Massachusetts Medical School.</p>
dc.description.abstractBACKGROUND: Mullerian inhibiting substance, produced constitutively by the prepubertal testes, promotes involution of the mullerian ducts during normal male sexual differentiation. In children with virilization and nonpalpable gonads, only those with testicular tissue should have detectable serum concentrations of mullerian inhibiting substance. METHODS: We measured serum mullerian inhibiting substance in 65 children with virilization at birth and nonpalpable gonads (age at diagnosis, 2 days to 11 years) and serum testosterone in 54 of them either after the administration of human chorionic gonadotropin or during the physiologic rise in testosterone that occurs in normal infants. RESULTS: The mean (+/-SD) serum mullerian inhibiting substance concentration in the 17 children with no testicular tissue was 0.7+/-0.5 ng per milliliter, as compared with 37.5+/-39.6 ng per milliliter in the 48 children with testes (P CONCLUSIONS: Measurements of serum mullerian inhibiting substance can be used to determine testicular status in prepubertal children with nonpalpable gonads, thus differentiating anorchia from undescended testes in boys with bilateral cryptorchidism and serving as a measure of testicular integrity in children with intersexual anomalies.
dc.language.isoen_US
dc.relation<p><a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=9154766&dopt=Abstract">Link to Article in PubMed</a></p>
dc.rightsCopyright © 1997 Massachusetts Medical Society. Published article PDF archived as allowed by the publisher's author permissions policy at https://www.nejm.org/author-center/permissions.
dc.subjectAnti-Mullerian Hormone
dc.subjectChild
dc.subjectChild, Preschool
dc.subjectCryptorchidism
dc.subjectDiagnosis, Differential
dc.subjectDisorders of Sex Development
dc.subjectFemale
dc.subject*Glycoproteins
dc.subjectGrowth Inhibitors
dc.subjectHumans
dc.subjectInfant
dc.subjectInfant, Newborn
dc.subjectMale
dc.subjectMullerian Ducts
dc.subjectSensitivity and Specificity
dc.subjectTesticular Hormones
dc.subjectTestis
dc.subjectTestosterone
dc.subjectVirilism
dc.subjectMullerian inhibiting substance
dc.subjectserum concentration
dc.subjectCell Biology
dc.subjectDevelopmental Biology
dc.subjectEndocrinology
dc.subjectEndocrinology, Diabetes, and Metabolism
dc.titleMeasurements of serum mullerian inhibiting substance in the evaluation of children with nonpalpable gonads
dc.typeJournal Article
dc.source.journaltitleThe New England journal of medicine
dc.source.volume336
dc.source.issue21
dc.identifier.legacyfulltexthttps://escholarship.umassmed.edu/cgi/viewcontent.cgi?article=1038&amp;context=lee&amp;unstamped=1
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/lee/39
dc.identifier.contextkey5771345
refterms.dateFOA2022-08-23T16:24:10Z
html.description.abstract<p>BACKGROUND: Mullerian inhibiting substance, produced constitutively by the prepubertal testes, promotes involution of the mullerian ducts during normal male sexual differentiation. In children with virilization and nonpalpable gonads, only those with testicular tissue should have detectable serum concentrations of mullerian inhibiting substance.</p> <p>METHODS: We measured serum mullerian inhibiting substance in 65 children with virilization at birth and nonpalpable gonads (age at diagnosis, 2 days to 11 years) and serum testosterone in 54 of them either after the administration of human chorionic gonadotropin or during the physiologic rise in testosterone that occurs in normal infants.</p> <p>RESULTS: The mean (+/-SD) serum mullerian inhibiting substance concentration in the 17 children with no testicular tissue was 0.7+/-0.5 ng per milliliter, as compared with 37.5+/-39.6 ng per milliliter in the 48 children with testes (P</p> <p>CONCLUSIONS: Measurements of serum mullerian inhibiting substance can be used to determine testicular status in prepubertal children with nonpalpable gonads, thus differentiating anorchia from undescended testes in boys with bilateral cryptorchidism and serving as a measure of testicular integrity in children with intersexual anomalies.</p>
dc.identifier.submissionpathlee/39
dc.contributor.departmentDepartment of Pediatrics
dc.source.pages1480-6


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