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dc.contributor.authorBurns, Jane S.
dc.contributor.authorWilliams, Paige L.
dc.contributor.authorSergeyev, Oleg
dc.contributor.authorKorrick, Susan
dc.contributor.authorLee, Mary M.
dc.contributor.authorRevich, Boris
dc.contributor.authorAltshul, Larisa
dc.contributor.authorDel Prato, Julie T.
dc.contributor.authorHumblet, Olivier
dc.contributor.authorPatterson, Donald G.
dc.contributor.authorTurner, Wayman E.
dc.contributor.authorStarovoytov, Mikhail
dc.contributor.authorHauser, Russ
dc.date2022-08-11T08:09:16.000
dc.date.accessioned2022-08-23T16:24:11Z
dc.date.available2022-08-23T16:24:11Z
dc.date.issued2011-10-01
dc.date.submitted2014-07-10
dc.identifier.citationEnviron Health Perspect. 2012 Feb;120(2):303-8. doi: 10.1289/ehp.1103743. Epub 2011 Oct 7. <a href="http://dx.doi.org/10.1289/ehp.1103743">Link to article on publisher's site</a>
dc.identifier.issn0091-6765 (Linking)
dc.identifier.doi10.1289/ehp.1103743
dc.identifier.pmid21984531
dc.identifier.urihttp://hdl.handle.net/20.500.14038/36065
dc.description.abstractBACKGROUND: Limited human data suggest an association of organochlorine pesticides (OCPs) with adverse effects on children's growth. OBJECTIVE: We evaluated the associations of OCPs with longitudinally assessed growth among peripubertal boys from a Russian cohort with high environmental OCP levels. METHODS: A cohort of 499 boys enrolled in the Russian Children's Study between 2003 and 2005 at 8-9 years of age were followed prospectively for 4 years. At study entry, 350 boys had serum OCPs measured. Physical examinations were conducted at entry and annually. The longitudinal associations of serum OCPs with annual measurements of body mass index (BMI), height, and height velocity were examined by multivariate mixed-effects regression models for repeated measures, controlling for potential confounders. RESULTS: Among the 350 boys with OCP measurements, median serum hexachlorobenzene (HCB), beta-hexachlorocyclohexane (betaHCH), and p,p -dichlorodiphenyldichloroethylene (p,p -DDE) concentrations were 159 ng/g lipid, 168 ng/g lipid, and 287 ng/g lipid, respectively. Age-adjusted BMI and height z-scores generally fell within the normal range per World Health Organization standards at entry and during follow-up. However, in adjusted models, boys with higher serum HCB, betaHCH, and p,p -DDE had significantly lower mean [95% confidence interval (CI)] BMI z-scores, by -0.84 (-1.23, -0.46), -1.32 (-1.70, -0.95), and -1.37 (-1.75, -0.98), respectively, for the highest versus lowest quintile. In addition, the highest quintile of p,p -DDE was associated with a significantly lower mean (95% CI) height z-score, by -0.69 (-1.00, -0.39) than that of the lowest quintile. CONCLUSIONS: Serum OCP concentrations measured at 8-9 years of age were associated with reduced growth, particularly reduced BMI, during the peripubertal period, which may affect attainment of optimal adult body mass and height.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=21984531&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1289/ehp.1103743
dc.subjectBody Height
dc.subjectBody Mass Index
dc.subjectChild
dc.subject*Child Development
dc.subject*Environmental Exposure
dc.subjectFollow-Up Studies
dc.subjectHumans
dc.subjectHydrocarbons, Chlorinated
dc.subjectMale
dc.subjectMultivariate Analysis
dc.subjectPesticides
dc.subjectProspective Studies
dc.subjectRussia
dc.subjectSensitivity and Specificity
dc.subjectCell Biology
dc.subjectDevelopmental Biology
dc.subjectEndocrinology
dc.titleSerum concentrations of organochlorine pesticides and growth among Russian boys
dc.typeJournal Article
dc.source.journaltitleEnvironmental health perspectives
dc.source.volume120
dc.source.issue2
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/lee/52
dc.identifier.contextkey5771359
html.description.abstract<p>BACKGROUND: Limited human data suggest an association of organochlorine pesticides (OCPs) with adverse effects on children's growth.</p> <p>OBJECTIVE: We evaluated the associations of OCPs with longitudinally assessed growth among peripubertal boys from a Russian cohort with high environmental OCP levels.</p> <p>METHODS: A cohort of 499 boys enrolled in the Russian Children's Study between 2003 and 2005 at 8-9 years of age were followed prospectively for 4 years. At study entry, 350 boys had serum OCPs measured. Physical examinations were conducted at entry and annually. The longitudinal associations of serum OCPs with annual measurements of body mass index (BMI), height, and height velocity were examined by multivariate mixed-effects regression models for repeated measures, controlling for potential confounders.</p> <p>RESULTS: Among the 350 boys with OCP measurements, median serum hexachlorobenzene (HCB), beta-hexachlorocyclohexane (betaHCH), and p,p -dichlorodiphenyldichloroethylene (p,p -DDE) concentrations were 159 ng/g lipid, 168 ng/g lipid, and 287 ng/g lipid, respectively. Age-adjusted BMI and height z-scores generally fell within the normal range per World Health Organization standards at entry and during follow-up. However, in adjusted models, boys with higher serum HCB, betaHCH, and p,p -DDE had significantly lower mean [95% confidence interval (CI)] BMI z-scores, by -0.84 (-1.23, -0.46), -1.32 (-1.70, -0.95), and -1.37 (-1.75, -0.98), respectively, for the highest versus lowest quintile. In addition, the highest quintile of p,p -DDE was associated with a significantly lower mean (95% CI) height z-score, by -0.69 (-1.00, -0.39) than that of the lowest quintile.</p> <p>CONCLUSIONS: Serum OCP concentrations measured at 8-9 years of age were associated with reduced growth, particularly reduced BMI, during the peripubertal period, which may affect attainment of optimal adult body mass and height.</p>
dc.identifier.submissionpathlee/52
dc.contributor.departmentDepartment of Pediatrics
dc.source.pages303-8


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