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    The increased incidence of congenital hypothyroidism: fact or fancy?

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    Authors
    Mitchell, Marvin L.
    Hsu, Ho-Wen
    Sahai, Inderneel
    Brink, Stuart J.
    Brown, Rosalind S.
    Cohen, Laurie E.
    Eaton, Roger B.
    Lee, Mary M.
    Levitsky, Lynne L.
    Reiter, Edward
    Sadeghi-Nejad, Abdollah
    Soyka, Leslie A.
    Wolfsdorf, Joseph I.
    Therrell, Bradford L.
    Show allShow less
    UMass Chan Affiliations
    Department of Pediatrics
    Document Type
    Journal Article
    Publication Date
    2011-05-27
    Keywords
    Child
    Cohort Studies
    Congenital Hypothyroidism
    Female
    Follow-Up Studies
    Humans
    Incidence
    Infant
    Infant, Newborn
    Male
    Massachusetts
    Neonatal Screening
    Severity of Illness Index
    Up-Regulation
    Cell Biology
    Congenital, Hereditary, and Neonatal Diseases and Abnormalities
    Developmental Biology
    Endocrine System Diseases
    Endocrinology
    Musculoskeletal Diseases
    Pediatrics
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    Link to Full Text
    https://doi.org/10.1111/j.1365-2265.2011.04128.x
    Abstract
    OBJECTIVE: The incidence of congenital hypothyroidism (CH) detected by newborn screening in the US has increased significantly since the early 1990s. We defined the characteristics associated with the increased incidence. PATIENTS: A cohort of children with CH born during an earlier period of low incidence (1991-94) was compared with a cohort born during a later period when the incidence of CH had doubled (2001-04). MEASUREMENTS: Screening was performed with T4 as the primary marker and thyroid stimulating hormone (TSH) on selected specimens. Follow-up on hypothyroid children determined whether they had permanent or transient hypothyroidism. Cases were classified based on laboratory results: initial TSH >/=100 mU/l was 'severe,' initial TSH /l but >/=20 mU/l was 'mild' and initial TSH /l with subsequent abnormal TSH was 'delayed'. RESULTS: The overall incidence of CH almost doubled between the two time periods, from 1:3010 to 1:1660. Excess cases were found in the mild and delayed categories, with no increase in severe cases. The proportion of transient cases was CONCLUSION: The rising incidence of CH in Massachusetts is confined to mild and delayed cases. Our findings suggest that this rise is attributable to enhanced detection rather than an absolute increase in numbers.
    Source

    Clin Endocrinol (Oxf). 2011 Dec;75(6):806-10. doi: 10.1111/j.1365-2265.2011.04128.x. Link to article on publisher's site

    DOI
    10.1111/j.1365-2265.2011.04128.x
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/36067
    PubMed ID
    21623857
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2265.2011.04128.x
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