Mullerian inhibiting substance: a gonadal hormone with multiple functions
UMass Chan Affiliations
Department of PediatricsDocument Type
Journal ArticlePublication Date
1993-04-01Keywords
AdolescentAdult
Amino Acid Sequence
Animals
Anti-Mullerian Hormone
Base Sequence
Child
Child, Preschool
Disorders of Sex Development
Female
Gene Expression Regulation
*Glycoproteins
Gonads
Growth Inhibitors
Humans
Infant
Infant, Newborn
Lung
Male
Molecular Sequence Data
Mullerian Ducts
Multigene Family
Testicular Hormones
Urogenital Neoplasms
Metadata
Show full item recordAbstract
Mullerian inhibiting substance (MIS) is the gonadal hormone that causes regression of the Mullerian ducts, the anlagen of the female internal reproductive structures, during male embryogenesis. MIS is a member of the large transforming growth factor-beta (TGF beta) multigene family of glycoproteins that are involved in the regulation of growth and differentiation. The proteins in this gene family are all produced as dimeric precursors and undergo posttranslational processing for activation, requiring cleavage and dissociation to release bioactive C-terminal fragments. Similarly, the 140 kilodalton (kDa) disulfide-linked homodimer of MIS is proteolytically cleaved to generate its active C-terminal fragments. The sexually dimorphic expression of MIS in Sertoli cells of the testis and granulosa cells of the ovary is critical for normal differentiation of the internal reproductive tract structures. A number of extra-Mullerian functions such as control of germ cell maturation and gonadal morphogenesis, induction of the abdominal phase of testicular descent, suppression of lung maturation, and growth inhibition of transformed cells have also been proposed for this growth-inhibitory hormone and will be discussed. This article will summarize the current understanding of the biology and multiple functions of MIS including its activation, regulation, and mechanism of action and discuss areas of interest in ongoing research.Source
Endocr Rev. 1993 Apr;14(2):152-64. Link to article on publisher's siteDOI
10.1210/edrv-14-2-152Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36073PubMed ID
8325249Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1210/edrv-14-2-152