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    Virus-like particle capsid proteins encoded by different L double-stranded RNAs of Saccharomyces cerevisiae: their roles in maintenance of M double-stranded killer plasmids

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    Authors
    El-Sherbeini, Mohamed
    Tipper, Donald J.
    Mitchell, Diane J.
    Bostian, Keith A.
    UMass Chan Affiliations
    Department of Microbiology and Physiological Systems
    Department of Molecular Genetics and Microbiology
    Document Type
    Journal Article
    Publication Date
    1984-12-01
    Keywords
    Microbiology
    Molecular Biology
    Physiology
    
    Metadata
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    Link to Full Text
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC369293/
    Abstract
    The plasmid determinants of killer phenotypes in type K1 and K2 killer yeast cells are the 1.9-kilobase (kb) M1 and 1.7-kb M2 double-stranded RNAs (dsRNAs), respectively. These are dependent for their maintenance and encapsidation, in Saccharomyces cerevisiae virus ScV-M1 or ScV-M2 virus-like particles, on the capsid provided by one of a group of moderately related 4.7-kb dsRNAs called LA. The L1A and L2A dsRNAs found in naturally isolated K1 and K2 killers encode 88-kilodalton VL1A-P1 and 86-kilodalton VL2A-P1 capsids, respectively. These are competent for encapsidating homologous LA dsRNAs as well as M dsRNAs. Most strains of S. cerevisiae, including killers, contain one of a second group of closely related 4.7-kb dsRNAs called LBC. These encode their own 82-kilodalton capsid protein, VLBC-P1, which, at least in strains containing only LBC, encapsidates homologous dsRNA in ScV-LBC virus-like particles. In a K1 killer strain containing both L1A and LBC, ScV-M1 particles contain only VL1A-P1. In such strains it is probable that each virus-like particle contains a single capsid type and that each L dsRNA is encapsidated by a homologous capsid.
    Source

    Mol Cell Biol. 1984 Dec;4(12):2818-27. doi: 10.1128/mcb.4.12.2818. Link to article on publisher's site

    DOI
    10.1128/mcb.4.12.2818
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/36469
    PubMed ID
    6396508
    Related Resources

    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1128/mcb.4.12.2818
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