Complex regulation and function of activation-induced cytidine deaminase
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Authors
Stavnezer, JanetUMass Chan Affiliations
Department of Microbiology and Physiological SystemsDocument Type
Journal ArticlePublication Date
2011-05-01Keywords
AnimalsB-Lymphocytes
Cytidine Deaminase
DNA, Superhelical
*Gene Expression Regulation, Enzymologic
Humans
Immunoglobulin Class Switching
Lymphocyte Activation
Mice
RNA Stability
Somatic Hypermutation, Immunoglobulin
Genetics and Genomics
Immunology and Infectious Disease
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Show full item recordAbstract
Activation-induced cytidine deaminase (AID) instigates mutations and DNA breaks in Ig genes that undergo somatic hypermutation and class switch recombination during B cell activation in response to immunization and infection. This review discusses how AID expression and activity are regulated, including recent discoveries of AID-interacting proteins that might recruit AID to Ig genes, and allow it to target both DNA strands. Also discussed is the accumulating evidence that AID binds to, mutates, and creates breaks at numerous non-Ig sites in the genome, which initiates cell transformation and malignancies.Source
Trends Immunol. 2011 May;32(5):194-201. doi: 10.1016/j.it.2011.03.003. Link to article on publisher's site
DOI
10.1016/j.it.2011.03.003Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36498PubMed ID
21493144Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/j.it.2011.03.003