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    Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation

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    Authors
    Irazoqui, Javier E.
    UMass Chan Affiliations
    Program in Innate Immunity
    Department of Microbiology and Physiological Systems
    Document Type
    Journal Article
    Publication Date
    2020-02-01
    Keywords
    TFEB
    TFE3
    transcription
    inflammation
    innate immunity
    infection
    Immunology and Infectious Disease
    Microbiology
    
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    Link to Full Text
    https://doi.org/10.1016/j.it.2019.12.003
    Abstract
    Microphthalmia/TFE (MiT) transcription factors (TFs), such as transcription factor EB (TFEB) and transcription factor E3 (TFE3), are emerging as key regulators of innate immunity and inflammation. Rapid progress in the field requires a focused update on the latest advances. Recent studies show that TFEB and TFE3 function in innate immune cells to regulate antibacterial and antiviral responses downstream of phagocytosis, interferon (IFN)-gamma, lipopolysaccharide (LPS), and adenosine receptors. Moreover, overexpression of TFEB or TFE3 can drive inflammation in vivo, such as in atherosclerosis, while in other scenarios they can perform anti-inflammatory functions. MiT factors may constitute potential therapeutic targets for a broad range of diseases; however, to harness their therapeutic potential, sophisticated ways to manipulate MiT factor activity safely and effectively must be developed.
    Source

    Trends Immunol. 2020 Feb;41(2):157-171. doi: 10.1016/j.it.2019.12.003. Epub 2020 Jan 17. Link to article on publisher's site

    DOI
    10.1016/j.it.2019.12.003
    Permanent Link to this Item
    http://hdl.handle.net/20.500.14038/36508
    PubMed ID
    31959514
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    Link to Article in PubMed

    ae974a485f413a2113503eed53cd6c53
    10.1016/j.it.2019.12.003
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