Key Roles of MiT Transcription Factors in Innate Immunity and Inflammation
AuthorsIrazoqui, Javier E.
UMass Chan AffiliationsProgram in Innate Immunity
Department of Microbiology and Physiological Systems
Immunology and Infectious Disease
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AbstractMicrophthalmia/TFE (MiT) transcription factors (TFs), such as transcription factor EB (TFEB) and transcription factor E3 (TFE3), are emerging as key regulators of innate immunity and inflammation. Rapid progress in the field requires a focused update on the latest advances. Recent studies show that TFEB and TFE3 function in innate immune cells to regulate antibacterial and antiviral responses downstream of phagocytosis, interferon (IFN)-gamma, lipopolysaccharide (LPS), and adenosine receptors. Moreover, overexpression of TFEB or TFE3 can drive inflammation in vivo, such as in atherosclerosis, while in other scenarios they can perform anti-inflammatory functions. MiT factors may constitute potential therapeutic targets for a broad range of diseases; however, to harness their therapeutic potential, sophisticated ways to manipulate MiT factor activity safely and effectively must be developed.
Trends Immunol. 2020 Feb;41(2):157-171. doi: 10.1016/j.it.2019.12.003. Epub 2020 Jan 17. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/36508