UMass Chan AffiliationsGraduate School of Biomedical Sciences
Program in Innate Immunity
Department of Microbiology and Physiological Systems
Document TypeResponse or Comment
MetadataShow full item record
AbstractDietary restriction (DR) extends lifespan in multiple animal species, but the underlying molecular mechanisms remain poorly understood. A recent study published in Cell Metabolism by Wu et al. (2019) shows that DR represses an evolutionarily conserved p38 MAPK pathway involved in innate immunity, leading to diminished expression of p38 MAPK-regulated genes and extended lifespan.
Mol Cell. 2019 Jun 6;74(5):864-865. doi: 10.1016/j.molcel.2019.05.012. Link to article on publisher's site
Permanent Link to this Itemhttp://hdl.handle.net/20.500.14038/36511