A Nutrition-Longevity Tradeoff Enforced by Innate Immunity

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Authors
Wani, Khursheed A
Goswamy, Debanjan
Irazoqui, Javier E
UMass Chan Affiliations
Graduate School of Biomedical Sciences
Program in Innate Immunity
Department of Microbiology and Physiological Systems
Document Type
Response or Comment
Publication Date
2019-06-06
Keywords
Immunology and Infectious Disease
Microbiology

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https://doi.org/10.1016/j.molcel.2019.05.012
Abstract
Dietary restriction (DR) extends lifespan in multiple animal species, but the underlying molecular mechanisms remain poorly understood. A recent study published in Cell Metabolism by Wu et al. (2019) shows that DR represses an evolutionarily conserved p38 MAPK pathway involved in innate immunity, leading to diminished expression of p38 MAPK-regulated genes and extended lifespan.
Source

Mol Cell. 2019 Jun 6;74(5):864-865. doi: 10.1016/j.molcel.2019.05.012. Link to article on publisher's site
DOI
10.1016/j.molcel.2019.05.012
Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36511
PubMed ID
31173721
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