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UMass Chan Affiliations
Department of Molecular, Cell, and Cancer BiologyDocument Type
Book ChapterPublication Date
2015-09-09Keywords
ApoptosisAtg genes
Autophagy
Caspase
Necrosis
Programmed cell death
Cell Biology
Cellular and Molecular Physiology
Developmental Biology
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Show full item recordAbstract
Macroautophagy (hereafter referred to as autophagy) is a process used by the cell to deliver cytoplasmic components to the lysosome for degradation. Autophagy is most often associated with cell survival, as it provides cells with molecular building blocks during periods of nutrient deprivation and also aids in the elimination of damaged organelles and protein aggregates. However, autophagy has also been implicated in cell death. Here, we review what is known about autophagy, its regulation, its role both in cell life and cell death, and what is known about autophagic cell death in vivo.Source
Curr Top Dev Biol. 2015;114:67-91. doi: 10.1016/bs.ctdb.2015.07.012. Epub 2015 Sep 9. Link to article on publisher's siteDOI
10.1016/bs.ctdb.2015.07.012Permanent Link to this Item
http://hdl.handle.net/20.500.14038/36539PubMed ID
26431564Related Resources
Link to Article in PubMedae974a485f413a2113503eed53cd6c53
10.1016/bs.ctdb.2015.07.012