Show simple item record

dc.contributor.authorAnding, Allyson L.
dc.contributor.authorBaehrecke, Eric H.
dc.date2022-08-11T08:09:19.000
dc.date.accessioned2022-08-23T16:26:19Z
dc.date.available2022-08-23T16:26:19Z
dc.date.issued2015-09-09
dc.date.submitted2015-11-30
dc.identifier.citationCurr Top Dev Biol. 2015;114:67-91. doi: 10.1016/bs.ctdb.2015.07.012. Epub 2015 Sep 9. <a href="http://dx.doi.org/10.1016/bs.ctdb.2015.07.012">Link to article on publisher's site</a>
dc.identifier.issn0070-2153 (Linking)
dc.identifier.doi10.1016/bs.ctdb.2015.07.012
dc.identifier.pmid26431564
dc.identifier.urihttp://hdl.handle.net/20.500.14038/36539
dc.description.abstractMacroautophagy (hereafter referred to as autophagy) is a process used by the cell to deliver cytoplasmic components to the lysosome for degradation. Autophagy is most often associated with cell survival, as it provides cells with molecular building blocks during periods of nutrient deprivation and also aids in the elimination of damaged organelles and protein aggregates. However, autophagy has also been implicated in cell death. Here, we review what is known about autophagy, its regulation, its role both in cell life and cell death, and what is known about autophagic cell death in vivo.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26431564&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1016/bs.ctdb.2015.07.012
dc.subjectApoptosis
dc.subjectAtg genes
dc.subjectAutophagy
dc.subjectCaspase
dc.subjectNecrosis
dc.subjectProgrammed cell death
dc.subjectCell Biology
dc.subjectCellular and Molecular Physiology
dc.subjectDevelopmental Biology
dc.titleAutophagy in Cell Life and Cell Death
dc.typeBook Chapter
dc.source.booktitleCurrent topics in developmental biology
dc.source.volume114
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/mccb_pubs/33
dc.identifier.contextkey7884834
html.description.abstract<p>Macroautophagy (hereafter referred to as autophagy) is a process used by the cell to deliver cytoplasmic components to the lysosome for degradation. Autophagy is most often associated with cell survival, as it provides cells with molecular building blocks during periods of nutrient deprivation and also aids in the elimination of damaged organelles and protein aggregates. However, autophagy has also been implicated in cell death. Here, we review what is known about autophagy, its regulation, its role both in cell life and cell death, and what is known about autophagic cell death in vivo.</p>
dc.identifier.submissionpathmccb_pubs/33
dc.contributor.departmentDepartment of Molecular, Cell, and Cancer Biology
dc.source.pages67-91


Files in this item

Thumbnail
Name:
Publisher version

This item appears in the following Collection(s)

Show simple item record