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Want reprogramming? Cut back on the chromatin assembly!
| dc.contributor.author | Kaufman, Paul D. | |
| dc.date | 2022-08-11T08:09:19.000 | |
| dc.date.accessioned | 2022-08-23T16:26:22Z | |
| dc.date.available | 2022-08-23T16:26:22Z | |
| dc.date.issued | 2015-09-01 | |
| dc.date.submitted | 2015-12-03 | |
| dc.identifier.citation | Nat Struct Mol Biol. 2015 Sep;22(9):648-50. doi: 10.1038/nsmb.3081. <a href="http://dx.doi.org/10.1038/nsmb.3081">Link to article on publisher's site</a> | |
| dc.identifier.issn | 1545-9985 (Linking) | |
| dc.identifier.doi | 10.1038/nsmb.3081 | |
| dc.identifier.pmid | 26333710 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14038/36550 | |
| dc.description.abstract | Totipotency, the ability of early embryonic cells to generate a complete adult organism as well as extraembryonic tissue, is a fleeting property found only in very early embryonic cells. A breakthrough study now shows that inhibition of DNA replication–linked nucleosome assembly causes embryonic stem cells to resemble totipotent cells. Notably, inhibition of chromatin assembly stimulates reprogramming during somatic-cell nuclear transfer experiments. | |
| dc.language.iso | en_US | |
| dc.relation | <a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26333710&dopt=Abstract">Link to Article in PubMed</a> | |
| dc.relation.url | http://dx.doi.org/10.1038/nsmb.3081 | |
| dc.subject | Biochemistry | |
| dc.subject | Cell Biology | |
| dc.subject | Developmental Biology | |
| dc.subject | Molecular Biology | |
| dc.subject | Structural Biology | |
| dc.title | Want reprogramming? Cut back on the chromatin assembly! | |
| dc.type | Journal Article | |
| dc.source.journaltitle | Nature structural and molecular biology | |
| dc.source.volume | 22 | |
| dc.source.issue | 9 | |
| dc.identifier.legacycoverpage | https://escholarship.umassmed.edu/mccb_pubs/46 | |
| dc.identifier.contextkey | 7899975 | |
| html.description.abstract | <p>Totipotency, the ability of early embryonic cells to generate a complete adult organism as well as extraembryonic tissue, is a fleeting property found only in very early embryonic cells. A breakthrough study now shows that inhibition of DNA replication–linked nucleosome assembly causes embryonic stem cells to resemble totipotent cells. Notably, inhibition of chromatin assembly stimulates reprogramming during somatic-cell nuclear transfer experiments.</p> | |
| dc.identifier.submissionpath | mccb_pubs/46 | |
| dc.contributor.department | Department of Molecular, Cell and Cancer Biology | |
| dc.source.pages | 648-50 |