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dc.contributor.authorKaufman, Paul D.
dc.date2022-08-11T08:09:19.000
dc.date.accessioned2022-08-23T16:26:22Z
dc.date.available2022-08-23T16:26:22Z
dc.date.issued2015-09-01
dc.date.submitted2015-12-03
dc.identifier.citationNat Struct Mol Biol. 2015 Sep;22(9):648-50. doi: 10.1038/nsmb.3081. <a href="http://dx.doi.org/10.1038/nsmb.3081">Link to article on publisher's site</a>
dc.identifier.issn1545-9985 (Linking)
dc.identifier.doi10.1038/nsmb.3081
dc.identifier.pmid26333710
dc.identifier.urihttp://hdl.handle.net/20.500.14038/36550
dc.description.abstractTotipotency, the ability of early embryonic cells to generate a complete adult organism as well as extraembryonic tissue, is a fleeting property found only in very early embryonic cells. A breakthrough study now shows that inhibition of DNA replication–linked nucleosome assembly causes embryonic stem cells to resemble totipotent cells. Notably, inhibition of chromatin assembly stimulates reprogramming during somatic-cell nuclear transfer experiments.
dc.language.isoen_US
dc.relation<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&list_uids=26333710&dopt=Abstract">Link to Article in PubMed</a>
dc.relation.urlhttp://dx.doi.org/10.1038/nsmb.3081
dc.subjectBiochemistry
dc.subjectCell Biology
dc.subjectDevelopmental Biology
dc.subjectMolecular Biology
dc.subjectStructural Biology
dc.titleWant reprogramming? Cut back on the chromatin assembly!
dc.typeJournal Article
dc.source.journaltitleNature structural and molecular biology
dc.source.volume22
dc.source.issue9
dc.identifier.legacycoverpagehttps://escholarship.umassmed.edu/mccb_pubs/46
dc.identifier.contextkey7899975
html.description.abstract<p>Totipotency, the ability of early embryonic cells to generate a complete adult organism as well as extraembryonic tissue, is a fleeting property found only in very early embryonic cells. A breakthrough study now shows that inhibition of DNA replication–linked nucleosome assembly causes embryonic stem cells to resemble totipotent cells. Notably, inhibition of chromatin assembly stimulates reprogramming during somatic-cell nuclear transfer experiments.</p>
dc.identifier.submissionpathmccb_pubs/46
dc.contributor.departmentDepartment of Molecular, Cell and Cancer Biology
dc.source.pages648-50


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